TY - JOUR
T1 - Plasma factor XIII level variations during menstrual cycle
AU - Sharief, Lava A T
AU - Lawrie, Andrew S.
AU - Mackie, Ian J.
AU - Halimeh, Susan
AU - Kappert, Guenther
AU - Smith, Colette
AU - Peyvandi, Flora
AU - Kadir, Rezan A.
PY - 2016/5/20
Y1 - 2016/5/20
N2 - Factor XIII (FXIII) has an important role in the control of bleeding through fibrin cross-linking; however, its effect within the menstrual cycle is not fully understood. Aim of this study is to examine changes in FXIII activity during normal menstrual cycles and correlate FXIII activity with menstrual blood loss. A total of 32 healthy normal women of reproductive age were recruited. Menstrual blood loss was measured using the pictorial blood-assessment chart (PBAC). A bleeding score questionnaire was also completed. Blood samples were taken during the menstrual, proliferative, periovulatory, secretory and premenstrual phase for assessment of FXIII level. The mean?±?SD FXIII level was lowest during menstrual and periovulatory phases (114?±?23 and 114?±?21?IU/dl, respectively). Mean FXIII level during the secretory and premenstrual phases were higher than the menstrual phase (P?=?0.036). Mean secretory FXIII was also significantly higher compared with the periovulatory phase (P?=?0.02). There was no significant correlation between FXIII level during the menstrual phase and age (P?=?0.53) or PBAC score (P?=?0.53). There were no significant differences in FXIII level during the menstrual phase between women with PBAC scores of at least 100 (n?=?14; mean 116?IU/dl) and women with PBAC scores less than 100 (n?=?18; mean 113?IU/dl). There was no correlation between FXIII level and bleeding scores. FXIII activity was lower during menstrual and periovulatory phase of the cycle. However, the small difference between mean values (8?IU/dl) would be unlikely to have a significant impact on diagnosis of FXIII deficiency and clinical management.
AB - Factor XIII (FXIII) has an important role in the control of bleeding through fibrin cross-linking; however, its effect within the menstrual cycle is not fully understood. Aim of this study is to examine changes in FXIII activity during normal menstrual cycles and correlate FXIII activity with menstrual blood loss. A total of 32 healthy normal women of reproductive age were recruited. Menstrual blood loss was measured using the pictorial blood-assessment chart (PBAC). A bleeding score questionnaire was also completed. Blood samples were taken during the menstrual, proliferative, periovulatory, secretory and premenstrual phase for assessment of FXIII level. The mean?±?SD FXIII level was lowest during menstrual and periovulatory phases (114?±?23 and 114?±?21?IU/dl, respectively). Mean FXIII level during the secretory and premenstrual phases were higher than the menstrual phase (P?=?0.036). Mean secretory FXIII was also significantly higher compared with the periovulatory phase (P?=?0.02). There was no significant correlation between FXIII level during the menstrual phase and age (P?=?0.53) or PBAC score (P?=?0.53). There were no significant differences in FXIII level during the menstrual phase between women with PBAC scores of at least 100 (n?=?14; mean 116?IU/dl) and women with PBAC scores less than 100 (n?=?18; mean 113?IU/dl). There was no correlation between FXIII level and bleeding scores. FXIII activity was lower during menstrual and periovulatory phase of the cycle. However, the small difference between mean values (8?IU/dl) would be unlikely to have a significant impact on diagnosis of FXIII deficiency and clinical management.
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U2 - 10.1097/MBC.0000000000000491
DO - 10.1097/MBC.0000000000000491
M3 - Article
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
SN - 0957-5235
ER -