Plasma fatty acids response to central volume expansion in salt-sensitive hypertension

Paolo Coruzzi, Lorenzo Brambilla, Valerio Brambilla, Massimo Gualerzi, Gianfranco Parati, Marco Di Rienzo, Emanuela Zanardi, Almerico Novarini

Research output: Contribution to journalArticlepeer-review


The purpose of the present study was to investigate the possible regulation of plasma fatty acids by an acute isotonic-isooncotic central volume expansion. We measured the levels of nonesterified fatty acids (NEFA) in plasma from 12 essential hypertensive patients subjected to water immersion (WI). Central hypervolemia by WI over 2 hours caused the levels of most NEFA to increase, concomitantly with a marked natriuretic and kaliuretic response. With respect to baseline values, serum insulin levels did not change during Wl, while there was a profound suppression of plasma renin activity (PRA) and plasma aldosterone. In addition, when individual NEFA percent increase was expressed as a function of salt-sensitivity index (calculated as the change in mean arterial pressure [MAP] divided by the change in urinary sodium excretion rate), a greater percent increase in stearic acid (r = .72, P <.009), palmitic acid (r = .83, P <.001), and palmitoleic acid (r = .58, P <.048) was found during WI in those hypertensive subjects showing higher salt-sensitivity index. Thus, by demonstrating that an acute isotonic-isooncotic volume expansion may induce a significant increase of most NEFA plasma levels, we suggest that volume expansion per se could be included among the well-recognized risk factors for cardiovascular morbid events.

Original languageEnglish
Pages (from-to)508-513
Number of pages6
Issue number4
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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