TY - JOUR
T1 - Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
AU - Eussen, Simone J P M
AU - Vollset, Stein Emil
AU - Igland, Jannicke
AU - Meyer, Klaus
AU - Fredriksen, Åse
AU - Ueland, Per Magne
AU - Jenab, Mazda
AU - Slimani, Nadia
AU - Boffetta, Paolo
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie Christine
AU - Morois, Sophie
AU - Weikert, Cornelia
AU - Pischon, Tobias
AU - Linseisen, Jakob
AU - Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Zilis, Demosthenes
AU - Katsoulis, Michael
AU - Palli, Domenico
AU - Berrino, Franco
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H M
AU - Bueno-de-Mesquita, H. Bas
AU - Van Duijnhoven, Fränzel J B
AU - Gram, Inger Torhild
AU - Skeie, Guri
AU - Lund, Eiliv
AU - González, Carlos A.
AU - Martínez, Carmen
AU - Dorronsoro, Miren
AU - Ardanaz, Eva
AU - Navarro, Carmen
AU - Rodríguez, Laudina
AU - Van Guelpen, Bethany
AU - Palmqvist, Richard
AU - Manjer, Jonas
AU - Ericson, Ulrika
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2010/5
Y1 - 2010/5
N2 - Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Results: Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; Ptrend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C→T, MTHFR1298A→C, MTR2756A→G, MTRR66A→G, and MTHFD11958G→A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC = 1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37); 0.34]. The SLC19A180G→A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59);
AB - Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Results: Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; Ptrend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C→T, MTHFR1298A→C, MTR2756A→G, MTRR66A→G, and MTHFD11958G→A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC = 1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37); 0.34]. The SLC19A180G→A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59);
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U2 - 10.1158/1055-9965.EPI-09-0841
DO - 10.1158/1055-9965.EPI-09-0841
M3 - Article
C2 - 20447924
AN - SCOPUS:77952019974
VL - 19
SP - 1328
EP - 1340
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 5
ER -