TY - JOUR
T1 - Plasma Ghrelin Concentratin in the Short-Term following Biliopancreatic Diversion
AU - Adami, Gian Franco
AU - Cordera, Renzo
AU - Marinari, Guiseppe
AU - Lamerini, Giovanni
AU - Andraghetti, Gabriella
AU - Scopinaro, Nicola
PY - 2003/12
Y1 - 2003/12
N2 - Background: Ghrelin is a hormone that increases food intake in rodents and in humans. After gastric bypass surgery, a marked decrease in circulating ghrelin levels has been observed, and It was suggested that this may contribute to the weight-reducing effect of gastric bypass. In this study, the changes in circulating ghrelin levels following biliopancreatic diversion (BPD) were Investigated. Materials and Methods: Serum ghrelin concentration was measured in obese patients prior to and 5 days and 2 months following BPD. Results: At the short-term following BPD, marked reduction of serum ghrelin was observed, while thereafter the values returned to initial levels. Conclusion: Unlike following reducing diet or gastric bypass, following BPD only an initial reduction of serum ghrelin concentration was observed, while at 2 months following the operation, when food intake had nearly completely resumed, the values returned to the preoperative levels. This is consistent with the hypothesis that ghrelin production from the stomach is greatly influenced by the direct contact of ingested food with the gastric cells.
AB - Background: Ghrelin is a hormone that increases food intake in rodents and in humans. After gastric bypass surgery, a marked decrease in circulating ghrelin levels has been observed, and It was suggested that this may contribute to the weight-reducing effect of gastric bypass. In this study, the changes in circulating ghrelin levels following biliopancreatic diversion (BPD) were Investigated. Materials and Methods: Serum ghrelin concentration was measured in obese patients prior to and 5 days and 2 months following BPD. Results: At the short-term following BPD, marked reduction of serum ghrelin was observed, while thereafter the values returned to initial levels. Conclusion: Unlike following reducing diet or gastric bypass, following BPD only an initial reduction of serum ghrelin concentration was observed, while at 2 months following the operation, when food intake had nearly completely resumed, the values returned to the preoperative levels. This is consistent with the hypothesis that ghrelin production from the stomach is greatly influenced by the direct contact of ingested food with the gastric cells.
KW - Bariatric surgery
KW - Biliopancreatic diversion
KW - Ghrelin
KW - Morbid obesity
KW - Obesity
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U2 - 10.1381/096089203322618713
DO - 10.1381/096089203322618713
M3 - Article
C2 - 14738676
AN - SCOPUS:0347517717
VL - 13
SP - 889
EP - 892
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 6
ER -