Plasma glutamine decreases immediately after surgery and is related to incisiveness

Emanuela Viggiano, Maria Beatrice Passavanti, Maria Caterina Pace, Pasquale Sansone, Giuseppe Spaziano, Alessandro Viggiano, Caterina Aurilio, Marcellino Monda, Andrea Viggiano, Vincenzo Pota, Bruno De Luca, Elena De Luca

Research output: Contribution to journalArticle

Abstract

Glutamine (gln) is the most abundant free amino acid in the blood. It is involved in important metabolic and biochemical processes, like cell proliferation and oxidative stress. Previous studies have demonstrated that gln concentration in human plasma decreases in several conditions such as sepsis, ischemia-reperfusion, trauma, major surgery and burn. The aim of the present work was to compare the acute effects of different types of surgical interventions and of anesthetization on blood gln concentration. Plasma samples from 88 subjects (30 males and 58 females) were collected before and after major or minor surgery and the gln concentration was analyzed with high-performance liquid chromatography. The results showed that plasma gln concentration after surgery was lower than pre-surgery values and that in major surgery the decrease of gln was higher than in minor surgery. No significant effect was shown for sex or type of anesthesia. These results demonstrate the importance of a gln supplementation before a surgical intervention and show that the amount of gln supplementation should also be adjusted based on the type of surgery.

Original languageEnglish
Pages (from-to)1988-1991
Number of pages4
JournalJournal of Cellular Physiology
Volume227
Issue number5
DOIs
Publication statusPublished - May 2012

Fingerprint

Glutamine
Surgery
Plasmas
Minor Surgical Procedures
Blood
Biochemical Phenomena
Plasma (human)
Oxidative stress
Cell proliferation
High performance liquid chromatography
Reperfusion
Sepsis
Oxidative Stress
Ischemia
Anesthesia
High Pressure Liquid Chromatography
Cell Proliferation
Amino Acids
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Viggiano, E., Passavanti, M. B., Pace, M. C., Sansone, P., Spaziano, G., Viggiano, A., ... De Luca, E. (2012). Plasma glutamine decreases immediately after surgery and is related to incisiveness. Journal of Cellular Physiology, 227(5), 1988-1991. https://doi.org/10.1002/jcp.22928

Plasma glutamine decreases immediately after surgery and is related to incisiveness. / Viggiano, Emanuela; Passavanti, Maria Beatrice; Pace, Maria Caterina; Sansone, Pasquale; Spaziano, Giuseppe; Viggiano, Alessandro; Aurilio, Caterina; Monda, Marcellino; Viggiano, Andrea; Pota, Vincenzo; De Luca, Bruno; De Luca, Elena.

In: Journal of Cellular Physiology, Vol. 227, No. 5, 05.2012, p. 1988-1991.

Research output: Contribution to journalArticle

Viggiano, E, Passavanti, MB, Pace, MC, Sansone, P, Spaziano, G, Viggiano, A, Aurilio, C, Monda, M, Viggiano, A, Pota, V, De Luca, B & De Luca, E 2012, 'Plasma glutamine decreases immediately after surgery and is related to incisiveness', Journal of Cellular Physiology, vol. 227, no. 5, pp. 1988-1991. https://doi.org/10.1002/jcp.22928
Viggiano E, Passavanti MB, Pace MC, Sansone P, Spaziano G, Viggiano A et al. Plasma glutamine decreases immediately after surgery and is related to incisiveness. Journal of Cellular Physiology. 2012 May;227(5):1988-1991. https://doi.org/10.1002/jcp.22928
Viggiano, Emanuela ; Passavanti, Maria Beatrice ; Pace, Maria Caterina ; Sansone, Pasquale ; Spaziano, Giuseppe ; Viggiano, Alessandro ; Aurilio, Caterina ; Monda, Marcellino ; Viggiano, Andrea ; Pota, Vincenzo ; De Luca, Bruno ; De Luca, Elena. / Plasma glutamine decreases immediately after surgery and is related to incisiveness. In: Journal of Cellular Physiology. 2012 ; Vol. 227, No. 5. pp. 1988-1991.
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