Plasma glutamine decreases immediately after surgery and is related to incisiveness

Emanuela Viggiano, Maria Beatrice Passavanti, Maria Caterina Pace, Pasquale Sansone, Giuseppe Spaziano, Alessandro Viggiano, Caterina Aurilio, Marcellino Monda, Andrea Viggiano, Vincenzo Pota, Bruno De Luca, Elena De Luca

Research output: Contribution to journalArticlepeer-review


Glutamine (gln) is the most abundant free amino acid in the blood. It is involved in important metabolic and biochemical processes, like cell proliferation and oxidative stress. Previous studies have demonstrated that gln concentration in human plasma decreases in several conditions such as sepsis, ischemia-reperfusion, trauma, major surgery and burn. The aim of the present work was to compare the acute effects of different types of surgical interventions and of anesthetization on blood gln concentration. Plasma samples from 88 subjects (30 males and 58 females) were collected before and after major or minor surgery and the gln concentration was analyzed with high-performance liquid chromatography. The results showed that plasma gln concentration after surgery was lower than pre-surgery values and that in major surgery the decrease of gln was higher than in minor surgery. No significant effect was shown for sex or type of anesthesia. These results demonstrate the importance of a gln supplementation before a surgical intervention and show that the amount of gln supplementation should also be adjusted based on the type of surgery.

Original languageEnglish
Pages (from-to)1988-1991
Number of pages4
JournalJournal of Cellular Physiology
Issue number5
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology


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