Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease

Anna Alisi, Valerio Nobili, Sara Ceccarelli, Nadia Panera, Cristiano De Stefanis, Rita De Vito, Roberta Vitali, Giorgio Bedogni, Clara Balsano, Salvatore Cucchiara, Laura Stronati

Research output: Contribution to journalArticle

Abstract

Non-alcoholic fatty liver disease (NAFLD) affects 3-12% of the general pediatric population. HMGB1 protein is presently considered a potent inflammatory mediator in several liver diseases, even if its role in NAFLD is still unknown in clinical studies. Here we investigated the relationships between circulating HMGB1, TGF-β and MCP-1 and liver damage in pediatric NAFLD. HMGB1, TGF-β and MCP-1 plasma levels were measured in 110 obese children with biopsy-proven NAFLD and 40 age-matched obese controls. HMGB1, TGF-β and MCP-1, ALT, AST and cholesterol plasma levels were significantly higher in NAFLD than in control children. A significant association between increased levels of HMGB1, TGF-β and MCP-1 and high degrees of fibrosis was found. In this study, we showed for the first time that circulating levels of HMGB1 were raised in children with NAFLD and strongly correlated with fibrosis and systemic inflammation.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalExpert Review of Molecular Diagnostics
Volume14
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • High mobility group box 1
  • Liver fibrosis
  • Monocyte chemoattractant protein-1
  • Non-alcoholic fatty liver disease
  • TGF β

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pathology and Forensic Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease'. Together they form a unique fingerprint.

  • Cite this