Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death

Maria Casadellà, Alessandro Cozzi-Lepri, Andrew Phillips, Marc Noguera-Julian, Markus Bickel, Dalibor Sedlacek, Kai Zilmer, Bonaventura Clotet, Jens D Lundgren, Roger Paredes, EuroSIDA in EuroCOORD, Mauro Zaccarelli, Andrea Antinori, Rosa Antonietta Acinapura, Maria Maddalena Plazzi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE: To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management.

DESIGN: Nested case-control study within the EuroSIDA cohort.

METHODS: Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling.

RESULTS: The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.

CONCLUSIONS: The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.

Original languageEnglish
Pages (from-to)e0166613
JournalPLoS One
Volume12
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

tropisms
Tropism
T-cells
Human immunodeficiency virus 1
HIV-1
Acquired Immunodeficiency Syndrome
death
Plasmas
RNA
Sampling
T-lymphocytes
Testing
T-Lymphocytes
Logistics
HIV
sampling
CD4 Lymphocyte Count
case-control studies
Case-Control Studies
Linear Models

Keywords

  • Acquired Immunodeficiency Syndrome
  • Adult
  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes
  • Disease Progression
  • Female
  • HIV-1
  • Humans
  • Male
  • Middle Aged
  • RNA, Viral
  • Viral Load
  • Viral Tropism
  • Journal Article

Cite this

Casadellà, M., Cozzi-Lepri, A., Phillips, A., Noguera-Julian, M., Bickel, M., Sedlacek, D., ... Plazzi, M. M. (2017). Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death. PLoS One, 12(1), e0166613. https://doi.org/10.1371/journal.pone.0166613

Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death. / Casadellà, Maria; Cozzi-Lepri, Alessandro; Phillips, Andrew; Noguera-Julian, Marc; Bickel, Markus; Sedlacek, Dalibor; Zilmer, Kai; Clotet, Bonaventura; Lundgren, Jens D; Paredes, Roger; EuroSIDA in EuroCOORD ; Zaccarelli, Mauro; Antinori, Andrea; Acinapura, Rosa Antonietta; Plazzi, Maria Maddalena.

In: PLoS One, Vol. 12, No. 1, 2017, p. e0166613.

Research output: Contribution to journalArticle

Casadellà, M, Cozzi-Lepri, A, Phillips, A, Noguera-Julian, M, Bickel, M, Sedlacek, D, Zilmer, K, Clotet, B, Lundgren, JD, Paredes, R, EuroSIDA in EuroCOORD, Zaccarelli, M, Antinori, A, Acinapura, RA & Plazzi, MM 2017, 'Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death', PLoS One, vol. 12, no. 1, pp. e0166613. https://doi.org/10.1371/journal.pone.0166613
Casadellà M, Cozzi-Lepri A, Phillips A, Noguera-Julian M, Bickel M, Sedlacek D et al. Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death. PLoS One. 2017;12(1):e0166613. https://doi.org/10.1371/journal.pone.0166613
Casadellà, Maria ; Cozzi-Lepri, Alessandro ; Phillips, Andrew ; Noguera-Julian, Marc ; Bickel, Markus ; Sedlacek, Dalibor ; Zilmer, Kai ; Clotet, Bonaventura ; Lundgren, Jens D ; Paredes, Roger ; EuroSIDA in EuroCOORD ; Zaccarelli, Mauro ; Antinori, Andrea ; Acinapura, Rosa Antonietta ; Plazzi, Maria Maddalena. / Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death. In: PLoS One. 2017 ; Vol. 12, No. 1. pp. e0166613.
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T1 - Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death

AU - Casadellà, Maria

AU - Cozzi-Lepri, Alessandro

AU - Phillips, Andrew

AU - Noguera-Julian, Marc

AU - Bickel, Markus

AU - Sedlacek, Dalibor

AU - Zilmer, Kai

AU - Clotet, Bonaventura

AU - Lundgren, Jens D

AU - Paredes, Roger

AU - EuroSIDA in EuroCOORD

AU - Zaccarelli, Mauro

AU - Antinori, Andrea

AU - Acinapura, Rosa Antonietta

AU - Plazzi, Maria Maddalena

PY - 2017

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N2 - OBJECTIVE: To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management.DESIGN: Nested case-control study within the EuroSIDA cohort.METHODS: Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling.RESULTS: The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.CONCLUSIONS: The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.

AB - OBJECTIVE: To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management.DESIGN: Nested case-control study within the EuroSIDA cohort.METHODS: Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling.RESULTS: The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.CONCLUSIONS: The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.

KW - Acquired Immunodeficiency Syndrome

KW - Adult

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - CD4-Positive T-Lymphocytes

KW - Disease Progression

KW - Female

KW - HIV-1

KW - Humans

KW - Male

KW - Middle Aged

KW - RNA, Viral

KW - Viral Load

KW - Viral Tropism

KW - Journal Article

U2 - 10.1371/journal.pone.0166613

DO - 10.1371/journal.pone.0166613

M3 - Article

VL - 12

SP - e0166613

JO - PLoS One

JF - PLoS One

SN - 1932-6203

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ER -