Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia

G. Ravaglia, P. Forti, F. Maioli, L. Servadei, M. Martelli, G. Arnone, T. Talerico, M. Zoli, E. Mariani

Research output: Contribution to journalArticle

Abstract

Increased levels of plasma total homocysteine (tHcy) may play a role in both cardiovascular diseases (CVD) and old-age dementias via enhancement of vascular inflammation. However, the association between plasma tHcy and serum C-reactive protein (sCRP), taken as a marker of low-grade inflammation, is still uncertain. We investigated this association in normal aging, CVD, and dementia, and examined whether it was modified by the presence of two major comorbid diseases of older age: chronic obstructive pulmonary disease (CPOD) and peptic ulcer (PU). Six hundred-twenty-seven individuals aged ≥ 65 yr (74±7 yr) were selected for this study: 373 healthy controls; 160 patients with CVD but no evidence of comorbid diseases (CVD+/comorbidity-); 46 patients with CVD and concurrent CPOD and/or PU (CVD+/comorbidity+); and 48 patients with dementia. A positive association between plasma tHcy and serum CRP, independent of several confounders (socio-demographic status, known tHcy and sCRP determinants, inflammation markers, traditional vascular risk factors), was found for CVD+/comorbidity+(p=0.042) and dementia (p=0.001; not affected by dementia type), but not for CVD+/comorbidity- and controls. The results suggest that the association between plasma tHcy and sCRP is more an aspecific reflection of poor health than a specific correlate of vascular inflammation.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalExperimental Gerontology
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Ageing
  • Atherosclerosis
  • Cardiovascular disease
  • Comorbidity
  • Dementia
  • Inflammation
  • Plasma total homocysteine
  • Serum C-reactive protein

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Fingerprint Dive into the research topics of 'Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia'. Together they form a unique fingerprint.

  • Cite this

    Ravaglia, G., Forti, P., Maioli, F., Servadei, L., Martelli, M., Arnone, G., Talerico, T., Zoli, M., & Mariani, E. (2004). Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia. Experimental Gerontology, 39(3), 443-450. https://doi.org/10.1016/j.exger.2003.11.005