Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia

G. Ravaglia, P. Forti, F. Maioli, L. Servadei, M. Martelli, G. Arnone, T. Talerico, M. Zoli, E. Mariani

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Increased levels of plasma total homocysteine (tHcy) may play a role in both cardiovascular diseases (CVD) and old-age dementias via enhancement of vascular inflammation. However, the association between plasma tHcy and serum C-reactive protein (sCRP), taken as a marker of low-grade inflammation, is still uncertain. We investigated this association in normal aging, CVD, and dementia, and examined whether it was modified by the presence of two major comorbid diseases of older age: chronic obstructive pulmonary disease (CPOD) and peptic ulcer (PU). Six hundred-twenty-seven individuals aged ≥ 65 yr (74±7 yr) were selected for this study: 373 healthy controls; 160 patients with CVD but no evidence of comorbid diseases (CVD+/comorbidity-); 46 patients with CVD and concurrent CPOD and/or PU (CVD+/comorbidity+); and 48 patients with dementia. A positive association between plasma tHcy and serum CRP, independent of several confounders (socio-demographic status, known tHcy and sCRP determinants, inflammation markers, traditional vascular risk factors), was found for CVD+/comorbidity+(p=0.042) and dementia (p=0.001; not affected by dementia type), but not for CVD+/comorbidity- and controls. The results suggest that the association between plasma tHcy and sCRP is more an aspecific reflection of poor health than a specific correlate of vascular inflammation.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalExperimental Gerontology
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Homocysteine
Dementia
Cardiovascular Diseases
Inflammation
Plasmas
Comorbidity
C-Reactive Protein
Blood Proteins
Peptic Ulcer
Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Blood Vessels
Demography
Aging of materials
Health
Serum

Keywords

  • Ageing
  • Atherosclerosis
  • Cardiovascular disease
  • Comorbidity
  • Dementia
  • Inflammation
  • Plasma total homocysteine
  • Serum C-reactive protein

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia. / Ravaglia, G.; Forti, P.; Maioli, F.; Servadei, L.; Martelli, M.; Arnone, G.; Talerico, T.; Zoli, M.; Mariani, E.

In: Experimental Gerontology, Vol. 39, No. 3, 03.2004, p. 443-450.

Research output: Contribution to journalArticle

Ravaglia, G, Forti, P, Maioli, F, Servadei, L, Martelli, M, Arnone, G, Talerico, T, Zoli, M & Mariani, E 2004, 'Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia', Experimental Gerontology, vol. 39, no. 3, pp. 443-450. https://doi.org/10.1016/j.exger.2003.11.005
Ravaglia, G. ; Forti, P. ; Maioli, F. ; Servadei, L. ; Martelli, M. ; Arnone, G. ; Talerico, T. ; Zoli, M. ; Mariani, E. / Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia. In: Experimental Gerontology. 2004 ; Vol. 39, No. 3. pp. 443-450.
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