Plasma homocysteine in patients with retinal vein occlusion

Giuseppe Minniti, Maria Grazia Calevo, Alessandro Giannattasio, Paola Camicione, Ugo Armani, Renata Lorini, Gianna Piana

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate total plasma homocysteine (HCY) during fasting and post methionine load test (MLT), serum folate, serum vitamin B12, and methylenetetrahydrofolate reductase (MTHFR) mutation in patients with retinal vein occlusion (RVO) and to examine the association between these risk factors and 2 subtypes of RVO: Central (CRVO) and branch (BRVO). Methods: This case-control study included 91 Italian patients presenting a first RVO and 71 healthy subjects, matched by age, without history of thromboembolic diseases, glaucoma, or malignancy. Homocysteine fasting and after MLT, serum folate level, serum vitamin B12 level, and other laboratory tests were assessed. Genetic analysis for the C677T MTHFR mutation was performed. results: Multivariate logistic regression analysis indicated that hypertension (odds ratio [OR] 2.63; 95% confidence interval [CI] 1.30-5.30; p = 0.007), higher values of fasting HCY (OR 1.16; 95% CI 1.01-1.33; p = 0.03), and low concentrations of vitamin B12 (OR 0.99; 95% CI 0.995-0.999; p = 0.01) were independently correlated with RVO. Moreover, the main determinants for CRVO risk were hyper-tension (OR 2.46; 95% CI 1.06-5.72; p = 0.04), high values of fasting HCY (OR 1.20; 95% CI 1.02-1.41; p = 0.03), and low concentrations of vitamin B12 (OR 0.99; 95% CI 0.994-0.999; p = 0.008), whereas for BRVO risk only hypertension was significant (OR 2.74; 95% CI 1.24-6.03; p = 0.01). Genotype distribution of the MTHFR C677T mutation did not reveal any significant difference between patients and controls. conclusions: These results suggest that elevated fasting HCY levels, low vitamin B12 levels, and hypertension are associated with a risk of RVO, especially for CRVO. Moreover, our data suggest that only hypertension is associated with BRVO risk.

Original languageEnglish
Pages (from-to)735-743
Number of pages9
JournalEuropean Journal of Ophthalmology
Issue number5
Publication statusPublished - Jan 30 2014


  • Branch retinal vein occlusion
  • Central retinal vein occlusion
  • Homocysteine
  • MTHFR C677T mutation
  • Retinal venous occlusion
  • Thrombosis
  • Vascular disease

ASJC Scopus subject areas

  • Ophthalmology


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