Plasma IL-5 concentration and subclinical carotid atherosclerosis

Angela Silveira, Olga McLeod, Rona J. Strawbridge, Karl Gertow, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Anna Deleskog, Jonas Persson, Karin Leander, Bruna Gigante, Jussi Kauhanen, Rainer Rauramaa, Andries J. Smit, Elmo Mannarino, Philippe Giral, Sven Gustafsson, Stefan Söderberg, John Öhrvik, Steve E. HumphriesElena Tremoli, Ulf de Faire, Anders Hamsten

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT). Methods: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n=3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline. Results: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women. Conclusions: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalAtherosclerosis
Volume239
Issue number1
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Carotid Artery Diseases
Interleukin-5
Carotid Intima-Media Thickness
Atherosclerosis
Coronary Artery Disease
Immunoassay
Hypersensitivity
Cohort Studies
Cardiovascular Diseases
Biomarkers
Databases
Prospective Studies

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Cytokines
  • Interleukin-5
  • Intima-media thickness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Silveira, A., McLeod, O., Strawbridge, R. J., Gertow, K., Sennblad, B., Baldassarre, D., ... Hamsten, A. (2015). Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis, 239(1), 125-130. https://doi.org/10.1016/j.atherosclerosis.2014.12.046

Plasma IL-5 concentration and subclinical carotid atherosclerosis. / Silveira, Angela; McLeod, Olga; Strawbridge, Rona J.; Gertow, Karl; Sennblad, Bengt; Baldassarre, Damiano; Veglia, Fabrizio; Deleskog, Anna; Persson, Jonas; Leander, Karin; Gigante, Bruna; Kauhanen, Jussi; Rauramaa, Rainer; Smit, Andries J.; Mannarino, Elmo; Giral, Philippe; Gustafsson, Sven; Söderberg, Stefan; Öhrvik, John; Humphries, Steve E.; Tremoli, Elena; de Faire, Ulf; Hamsten, Anders.

In: Atherosclerosis, Vol. 239, No. 1, 01.03.2015, p. 125-130.

Research output: Contribution to journalArticle

Silveira, A, McLeod, O, Strawbridge, RJ, Gertow, K, Sennblad, B, Baldassarre, D, Veglia, F, Deleskog, A, Persson, J, Leander, K, Gigante, B, Kauhanen, J, Rauramaa, R, Smit, AJ, Mannarino, E, Giral, P, Gustafsson, S, Söderberg, S, Öhrvik, J, Humphries, SE, Tremoli, E, de Faire, U & Hamsten, A 2015, 'Plasma IL-5 concentration and subclinical carotid atherosclerosis', Atherosclerosis, vol. 239, no. 1, pp. 125-130. https://doi.org/10.1016/j.atherosclerosis.2014.12.046
Silveira, Angela ; McLeod, Olga ; Strawbridge, Rona J. ; Gertow, Karl ; Sennblad, Bengt ; Baldassarre, Damiano ; Veglia, Fabrizio ; Deleskog, Anna ; Persson, Jonas ; Leander, Karin ; Gigante, Bruna ; Kauhanen, Jussi ; Rauramaa, Rainer ; Smit, Andries J. ; Mannarino, Elmo ; Giral, Philippe ; Gustafsson, Sven ; Söderberg, Stefan ; Öhrvik, John ; Humphries, Steve E. ; Tremoli, Elena ; de Faire, Ulf ; Hamsten, Anders. / Plasma IL-5 concentration and subclinical carotid atherosclerosis. In: Atherosclerosis. 2015 ; Vol. 239, No. 1. pp. 125-130.
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AU - Silveira, Angela

AU - McLeod, Olga

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AU - Baldassarre, Damiano

AU - Veglia, Fabrizio

AU - Deleskog, Anna

AU - Persson, Jonas

AU - Leander, Karin

AU - Gigante, Bruna

AU - Kauhanen, Jussi

AU - Rauramaa, Rainer

AU - Smit, Andries J.

AU - Mannarino, Elmo

AU - Giral, Philippe

AU - Gustafsson, Sven

AU - Söderberg, Stefan

AU - Öhrvik, John

AU - Humphries, Steve E.

AU - Tremoli, Elena

AU - de Faire, Ulf

AU - Hamsten, Anders

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N2 - Objective: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT). Methods: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n=3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline. Results: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women. Conclusions: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease.

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KW - Intima-media thickness

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