Plasma infusion for hemolytic-uremic syndrome in children: Results of a multicenter controlled trial

G. Rizzoni, A. Claris-Appiani, A. Edefonti, P. Facchin, F. Franchini, R. Gusmano, E. Imbasciati, L. Pavanello, F. Perfumo, G. Remuzzi

Research output: Contribution to journalArticle

Abstract

The results of a controlled trial to ascertain the usefulness of plasma infusion for the treatment of hemolytic-uremic syndrome (HUS) are reported. Criteria for admission were (1) observation within 8 days from first symptoms, (2) dialysis treatment required, and (3) no special treatments and no more than 25 ml blood/kg previously received. Children were subdivided according to age (less than or more than 3 years) and then randomly assigned to treatment with plasma or symptomatic therapy. Thirty-two children ranging in age from 4 months to 6 years entered this study; 17 received plasma (P+ group) and 15 only symptomatic therapy (P- group). The mean follow-up period was 16 months in both groups. Surgical renal biopsy was performed 29 to 49 days after onset in 11P+ and 11P- children, and 33 histologic findings were semiquantitatively evaluated. No death occurred in either group. No differences were found in blood pressure, proteinuria, or hematuria at the end of the follow-up period; in no case were severe arteriolar lesions found. There were no significant differences for the scores of the individual histologic measurements; on electron microscopy, no vascular changes were observed in seven children of the P+ group, whereas in five of seven of the P- group, thickening of the lamina rara interna and arteriolar damage were present. The ability of plasma to stimulate prostacyclin (PGl2) production, measured as its stable derivative 6-keto-PGF, was within the normal range for all patients. In our patients with predominant glomerular involvement who were treated in a very early phase of HUS, infusions of plasma did not significantly influence the short- and mediumterm clinical outcome and were not effective in severe HUS when given later in the course of the disease. A longer follow-up is needed to ascertain whether the presence of endothelial damage, demonstrated by electron microscopy in children who were not given plasma, is of clinical relevance.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalJournal of Pediatrics
Volume112
Issue number2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Rizzoni, G., Claris-Appiani, A., Edefonti, A., Facchin, P., Franchini, F., Gusmano, R., Imbasciati, E., Pavanello, L., Perfumo, F., & Remuzzi, G. (1988). Plasma infusion for hemolytic-uremic syndrome in children: Results of a multicenter controlled trial. Journal of Pediatrics, 112(2), 284-290. https://doi.org/10.1016/S0022-3476(88)80071-4