Plasma kinetics and urinary elimination of saccharin in man

C. Pantarotto, M. Salmona, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The plasma kinetics and urinary elimination of saccharin were studied in 3 groups each of 5 healthy male volunteers given the sweetener as three different single oral doses (50, 150 and 333 mg 60 kg body weight). Saccharin concentrations were determined by gas liquid chromatography-stable isotope dilution mass fragmentography. The compound was rapidly absorbed through the gastrointestinal tract, reaching plasma peak concentrations between 30 and 60 min after intake. Plasma saccharin elimination was also fast, with a monoexponential pattern of decay. At the 3 doses studied saccharin was excreted in urine within a few hours, about 60% of the dose being excreted unchanged at 6 h and 76% at 24 h.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalToxicology Letters
Volume9
Issue number4
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Toxicology

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