Plasma lactoferrin levels in newborn preterm infants with sepsis

L. Decembrino, M. DeAmici, A. De Silvestri, P. Manzoni, P. Paolillo, M. Stronati

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Lactoferrin (Lf) is one of the major proteins of all exocrine secretions with a role in the antinfective process. Our aim was to evaluate how plasma Fl levels may change in response to infection in newborn preterm infants. METHODS: A total of 15 (8 females, 7 males) newborn preterm infants with a postnatal age >72 h of life, underwent to blood culture and others markers of infection, for suspected sepsis, were enrolled in the study. RESULTS: We found that Lf serum concentration was significantly lowest in four neonates (26.7%) with confirmed sepsis than in 11 (73.3%) with clinical sepsis. The AUC was 0.90 (95%CI: 0.63-0.99). The optimal cutoff for Lf was
Original languageEnglish
Pages (from-to)2890-2893
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume30
Issue number23
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Lactoferrin
  • immune system
  • newborn preterm infants
  • sepsis

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