Plasma lactoferrin levels in newborn preterm infants with sepsis

L. Decembrino; M. DeAmici; A. De Silvestri; P. Manzoni; P. Paolillo; M. Stronati

doi:10.1080/14767058.2016.1266479 [doi]

Plasma lactoferrin levels in newborn preterm infants with sepsis

L. Decembrino, M. DeAmici, A. De Silvestri, P. Manzoni, P. Paolillo, M. Stronati

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Lactoferrin (Lf) is one of the major proteins of all exocrine secretions with a role in the antinfective process. Our aim was to evaluate how plasma Fl levels may change in response to infection in newborn preterm infants. METHODS: A total of 15 (8 females, 7 males) newborn preterm infants with a postnatal age >72 h of life, underwent to blood culture and others markers of infection, for suspected sepsis, were enrolled in the study. RESULTS: We found that Lf serum concentration was significantly lowest in four neonates (26.7%) with confirmed sepsis than in 11 (73.3%) with clinical sepsis. The AUC was 0.90 (95%CI: 0.63-0.99). The optimal cutoff for Lf was

Original language	English
Pages (from-to)	2890-2893
Number of pages	4
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	30
Issue number	23
DOIs	https://doi.org/10.1080/14767058.2016.1266479 [doi]
Publication status	Published - Dec 1 2017

Keywords

Lactoferrin
immune system
newborn preterm infants
sepsis

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10.1080/14767058.2016.1266479 [doi]

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title = "Plasma lactoferrin levels in newborn preterm infants with sepsis",

abstract = "INTRODUCTION: Lactoferrin (Lf) is one of the major proteins of all exocrine secretions with a role in the antinfective process. Our aim was to evaluate how plasma Fl levels may change in response to infection in newborn preterm infants. METHODS: A total of 15 (8 females, 7 males) newborn preterm infants with a postnatal age >72 h of life, underwent to blood culture and others markers of infection, for suspected sepsis, were enrolled in the study. RESULTS: We found that Lf serum concentration was significantly lowest in four neonates (26.7%) with confirmed sepsis than in 11 (73.3%) with clinical sepsis. The AUC was 0.90 (95%CI: 0.63-0.99). The optimal cutoff for Lf was ",

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AU - Decembrino, L.

AU - DeAmici, M.

AU - Silvestri, A. De

AU - Manzoni, P.

AU - Paolillo, P.

AU - Stronati, M.

N1 - LR: 20170925; JID: 101136916; OTO: NOTNLM; 2016/12/21 06:00 [pubmed]; 2016/12/21 06:00 [medline]; 2016/12/21 06:00 [entrez]; ppublish

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N2 - INTRODUCTION: Lactoferrin (Lf) is one of the major proteins of all exocrine secretions with a role in the antinfective process. Our aim was to evaluate how plasma Fl levels may change in response to infection in newborn preterm infants. METHODS: A total of 15 (8 females, 7 males) newborn preterm infants with a postnatal age >72 h of life, underwent to blood culture and others markers of infection, for suspected sepsis, were enrolled in the study. RESULTS: We found that Lf serum concentration was significantly lowest in four neonates (26.7%) with confirmed sepsis than in 11 (73.3%) with clinical sepsis. The AUC was 0.90 (95%CI: 0.63-0.99). The optimal cutoff for Lf was

AB - INTRODUCTION: Lactoferrin (Lf) is one of the major proteins of all exocrine secretions with a role in the antinfective process. Our aim was to evaluate how plasma Fl levels may change in response to infection in newborn preterm infants. METHODS: A total of 15 (8 females, 7 males) newborn preterm infants with a postnatal age >72 h of life, underwent to blood culture and others markers of infection, for suspected sepsis, were enrolled in the study. RESULTS: We found that Lf serum concentration was significantly lowest in four neonates (26.7%) with confirmed sepsis than in 11 (73.3%) with clinical sepsis. The AUC was 0.90 (95%CI: 0.63-0.99). The optimal cutoff for Lf was

KW - Lactoferrin

KW - immune system

KW - newborn preterm infants

KW - sepsis

U2 - 10.1080/14767058.2016.1266479 [doi]

DO - 10.1080/14767058.2016.1266479 [doi]

M3 - Article

VL - 30

SP - 2890

EP - 2893

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 23

ER -

Plasma lactoferrin levels in newborn preterm infants with sepsis

Abstract

Keywords

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