Plasma Leptin Levels after Vertical Banded Gastroplasty for Morbid Obesity: Effects of an Acidified Meal

Diego Foschi; Fabio Corsi; Laura Pisoni; Tarcisio Vago; Maurizio Bevilacqua; Andrea Trabucchi; Emanuele Asti; Emilio Trabucchi

doi:10.1381/096089203322618696

Plasma Leptin Levels after Vertical Banded Gastroplasty for Morbid Obesity: Effects of an Acidified Meal

Diego Foschi, Fabio Corsi, Laura Pisoni, Tarcisio Vago, Maurizio Bevilacqua, Andrea Trabucchi, Emanuele Asti, Emilio Trabucchi

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article

Abstract

Background: Leptin is considered one of the anorectic messengers to the central nervous system in lean subjects. Although it is secreted by the gastric mucosa, there are contradictory evidences of its involvement in mediating the acute satiety effect of the meal in obese patients. The effects of restrictive operations on meal-stimulated leptin secretion are unknown. Methods: The effects of a standard acidified (pH 3) meal on leptin release were investigated in obese patients, before and after vertical banded gastroplasty (VBG). 8 morbidly obese patients (BMI 49.1±6.5) had serum leptin determination after an overnight fast Samples were taken basally and every 30 minutes after the meal for 3 hours. The test was repeated after 20% BMI reduction. 5 lean volunteers (BMI 22.5±1.7) served as the control group. Results: In obese patients, basal serum leptin fell from 62±20.4 to 23.8±15.7 ng/ml after the operation (P

Original language	English
Pages (from-to)	874-878
Number of pages	5
Journal	Obesity Surgery
Volume	13
Issue number	6
DOIs	https://doi.org/10.1381/096089203322618696
Publication status	Published - Dec 2003

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Keywords

Bariatric surgery
Gastroplasty
Leptin
Meal
Morbid obesity
Stomach

ASJC Scopus subject areas

Surgery

Cite this

Foschi, D., Corsi, F., Pisoni, L., Vago, T., Bevilacqua, M., Trabucchi, A., Asti, E., & Trabucchi, E. (2003). Plasma Leptin Levels after Vertical Banded Gastroplasty for Morbid Obesity: Effects of an Acidified Meal. Obesity Surgery, 13(6), 874-878. https://doi.org/10.1381/096089203322618696

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abstract = "Background: Leptin is considered one of the anorectic messengers to the central nervous system in lean subjects. Although it is secreted by the gastric mucosa, there are contradictory evidences of its involvement in mediating the acute satiety effect of the meal in obese patients. The effects of restrictive operations on meal-stimulated leptin secretion are unknown. Methods: The effects of a standard acidified (pH 3) meal on leptin release were investigated in obese patients, before and after vertical banded gastroplasty (VBG). 8 morbidly obese patients (BMI 49.1±6.5) had serum leptin determination after an overnight fast Samples were taken basally and every 30 minutes after the meal for 3 hours. The test was repeated after 20% BMI reduction. 5 lean volunteers (BMI 22.5±1.7) served as the control group. Results: In obese patients, basal serum leptin fell from 62±20.4 to 23.8±15.7 ng/ml after the operation (P",

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AU - Foschi, Diego

AU - Corsi, Fabio

AU - Pisoni, Laura

AU - Vago, Tarcisio

AU - Bevilacqua, Maurizio

AU - Trabucchi, Andrea

AU - Asti, Emanuele

AU - Trabucchi, Emilio

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N2 - Background: Leptin is considered one of the anorectic messengers to the central nervous system in lean subjects. Although it is secreted by the gastric mucosa, there are contradictory evidences of its involvement in mediating the acute satiety effect of the meal in obese patients. The effects of restrictive operations on meal-stimulated leptin secretion are unknown. Methods: The effects of a standard acidified (pH 3) meal on leptin release were investigated in obese patients, before and after vertical banded gastroplasty (VBG). 8 morbidly obese patients (BMI 49.1±6.5) had serum leptin determination after an overnight fast Samples were taken basally and every 30 minutes after the meal for 3 hours. The test was repeated after 20% BMI reduction. 5 lean volunteers (BMI 22.5±1.7) served as the control group. Results: In obese patients, basal serum leptin fell from 62±20.4 to 23.8±15.7 ng/ml after the operation (P

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10.1381/096089203322618696