Plasma Leptin Levels after Vertical Banded Gastroplasty for Morbid Obesity: Effects of an Acidified Meal

Diego Foschi, Fabio Corsi, Laura Pisoni, Tarcisio Vago, Maurizio Bevilacqua, Andrea Trabucchi, Emanuele Asti, Emilio Trabucchi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Leptin is considered one of the anorectic messengers to the central nervous system in lean subjects. Although it is secreted by the gastric mucosa, there are contradictory evidences of its involvement in mediating the acute satiety effect of the meal in obese patients. The effects of restrictive operations on meal-stimulated leptin secretion are unknown. Methods: The effects of a standard acidified (pH 3) meal on leptin release were investigated in obese patients, before and after vertical banded gastroplasty (VBG). 8 morbidly obese patients (BMI 49.1±6.5) had serum leptin determination after an overnight fast Samples were taken basally and every 30 minutes after the meal for 3 hours. The test was repeated after 20% BMI reduction. 5 lean volunteers (BMI 22.5±1.7) served as the control group. Results: In obese patients, basal serum leptin fell from 62±20.4 to 23.8±15.7 ng/ml after the operation (P

Original languageEnglish
Pages (from-to)874-878
Number of pages5
JournalObesity Surgery
Volume13
Issue number6
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Bariatric surgery
  • Gastroplasty
  • Leptin
  • Meal
  • Morbid obesity
  • Stomach

ASJC Scopus subject areas

  • Surgery

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