The relationship between plasma atrial natriuretic factor (ANF), blood pressure (BP), age, plasma renin activity (PRA) and urinary sodium excretion was studied in 64 normal subjects (mean age 48.7 ± 2.1 yrs; BP: 126.5 ± 1.6/79.5 ± 0.9 mmHg) and in 104 untreated uncomplicated essential hypertensives (50.8 ± 1.1 yrs; BP: 164.7 ± 1.6/105.2 ± 0.6 mmHg). ANF was measured by radioimmunoassay after extraction on C18 columns. ANF was significantly higher in the hypertensives than in the normal subjects (37.1 ± 1.2 vs 29.7 ± 1.5 pg/ml, P <0.01). In normal plasma ANF was significantly correlated with age (r = 0.72, P <0.001), Na excretion (r = 0.42, P <0.001) and PRA (r = -0.71, P <0.001) whereas in the hypertensives ANF plasma levels correlated only with systolic (r = 0.46, P <0.001) and diastolic (r = 0.51, P <0.001) BP. In addition in hypertensive patients, by multivariate linear regression analysis, a significant correlation was found between age, known duration of hypertension and plasma ANF. The partial correlation coefficient between duration of hypertension and plasma ANF was highly significant (r = 0.80, P <0.001). These findings suggest that in essential hypertension the level of arterial BP is a main determinant of the ANF plasma values offsetting the ability of other physiological factors to regulate plasma ANF levels.
|Number of pages||6|
|Journal||Journal of Human Hypertension|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Internal Medicine