Livelli plasmatici di beta-endorfina basali e dopo sforzo in pazienti con disfunzione ventricolare sinistra severa e scompenso cardiaco.

Translated title of the contribution: Plasma levels of basal beta-endorphin and after effort in patients with severe left ventricular dysfunction and heart failure

G. P. Perna, S. Modoni, G. Valle, M. Stanislao, G. de Luca, R. Fanelli, F. Loperfido

Research output: Contribution to journalArticle

Abstract

BACKGROUNDS. Purpose of the study was to evaluate beta-endorphin plasma levels at rest and after exercise, and the beta-endorphin release, in relation to exercise capacity, in patients with severe left ventricular dysfunction and heart failure. METHODS. Beta-endorphin plasma levels were assayed by radio-immunoassay before and after cardiopulmonary exercise testing in 28 heart failure patients with radionuclide ejection fraction <35%, left ventricular end-dyastolic dimension > 60 mm and heart failure, and in 9 age-matched normal subjects. According to Weber's classification, 10 patients were in class A, 9 in class B, and 9 in class C. RESULTS. Beta-endorphin plasma levels at rest were respectively 3.52 +/- 2.31 pmol/L in patients, and 1.77 +/- 0.84 pmol/L (p <0.05) in normals. In patients, baseline beta-endorphin correlated to VO2max (r = -0.76), peak rate-pressure product (r = -0.60) and exercise time (r = -0.56), then progressively increasing from class A to C. After exercise, beta-endorphin plasma levels increased respectively to 6.42 +/- 3.44 pmol/L (p <0.001 vs baseline) in patients, and to 5.46 +/- 2.14 pmol/L (p <0.001 vs baseline and NS vs patients) in normals. In patients, the release during exercise of beta-endorphin (exercise - baseline/baseline x 100) correlated to VO2max (r = 0.82), peak rate-pressure product (r = 0.64) and exercise time (r = 0.55), then progressively decreasing from class A to C. At multivariate analysis beta-endorphin release showed the greater correlation to exercise capacity parameters. CONCLUSIONS. In heart failure patients, beta-endorphin plasma levels are elevated at rest and its release during exercise is reduced in relation to functional impairment.

Original languageItalian
Pages (from-to)1077-1085
Number of pages9
JournalGiornale Italiano di Cardiologia
Volume24
Issue number9
Publication statusPublished - Sep 1994

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Perna, G. P., Modoni, S., Valle, G., Stanislao, M., de Luca, G., Fanelli, R., & Loperfido, F. (1994). Livelli plasmatici di beta-endorfina basali e dopo sforzo in pazienti con disfunzione ventricolare sinistra severa e scompenso cardiaco. Giornale Italiano di Cardiologia, 24(9), 1077-1085.