Plasma levels of di-n-propylacetate (DPA) and clonazepam (CNP) and associated antiepileptic drugs were measured in groups of respectively 106 and 30 epileptic patients aged from 3 to 49 yr. A poor correlation between daily oral doses and plasma levels of both drugs was observed when the whole group of patients was considered. A better correlation was seen in a group of adult patients who received DPA and phenobarbital (PB). Children below 10 yr of age disposed both drugs faster than adults and the difference was significant (p <0.01) in groups receiving PB as associated drug. Patients medicated with PB and DPA or CNP showed lower plasma levels of both drugs; on the other hand DPA appeared to cause a decrease of PB clearance which was more marked in children. The clinical significance of the fluctuations of daily plasma levels of both drugs are discussed in relationship to the schedule of administration and plasma sampling. Observations on the therapeutic ranges and adverse effect of the drugs are reported.
|Number of pages||6|
|Journal||International Journal of Clinical Pharmacology Therapy and Toxicology|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Pharmacology (medical)