Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease

A. Mazzone, S. De Servi, M. Vezzoli, G. Fossati, I. Mazzucchelli, D. Gritti, E. Ottini, A. Mussini, G. Specchia

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to assess lymphocyte receptors expression in patients with ischemic heart diseases, as well as to measure the plasma levels of interleukin (IL) 2, 6 and 10. T Lymphocytes are found in large numbers in human atherosclerotic plaques, indicating that immune and inflammatory mechanisms are important factors in the pathogenesis of atherosclerosis. Recent data have also implicated T lymphocytes in the pathogenetic mechanism of unstable angina and ischemic heart disease. Three groups of patients were studied: 42 with an acute ischemic syndrome (AIS), 36 with stable angina (SA) and 39 healthy controls. To characterize lymphocyte phenotype, flow cytometry was performed in whole-blood samples. IL-2, IL-6 and IL-10 were measured using the ELISA method. Double fluorescence evaluation showed an increase in CD8+/CD11b+ cells (cytotoxic T lymphocytes) and in CD11b+/CD16+CD56+ cells (NK lymphocytes) in the AIS group and in SA group as compared to the control group (P

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalAtherosclerosis
Volume145
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Atherosclerosis
  • Cytokines
  • Ischemic heart diseases
  • T Lymphocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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