Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease

A. Mazzone, S. De Servi, M. Vezzoli, G. Fossati, I. Mazzucchelli, D. Gritti, E. Ottini, A. Mussini, G. Specchia

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Abstract

The purpose of this study was to assess lymphocyte receptors expression in patients with ischemic heart diseases, as well as to measure the plasma levels of interleukin (IL) 2, 6 and 10. T Lymphocytes are found in large numbers in human atherosclerotic plaques, indicating that immune and inflammatory mechanisms are important factors in the pathogenesis of atherosclerosis. Recent data have also implicated T lymphocytes in the pathogenetic mechanism of unstable angina and ischemic heart disease. Three groups of patients were studied: 42 with an acute ischemic syndrome (AIS), 36 with stable angina (SA) and 39 healthy controls. To characterize lymphocyte phenotype, flow cytometry was performed in whole-blood samples. IL-2, IL-6 and IL-10 were measured using the ELISA method. Double fluorescence evaluation showed an increase in CD8+/CD11b+ cells (cytotoxic T lymphocytes) and in CD11b+/CD16+CD56+ cells (NK lymphocytes) in the AIS group and in SA group as compared to the control group (P

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalAtherosclerosis
Volume145
Issue number2
DOIs
Publication statusPublished - 1999

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Interleukin-2
Myocardial Ischemia
Interleukin-6
Stable Angina
Lymphocytes
T-Lymphocytes
Interleukin-10
Unstable Angina
Cytotoxic T-Lymphocytes
Atherosclerotic Plaques
Natural Killer Cells
Atherosclerosis
Flow Cytometry
Fluorescence
Enzyme-Linked Immunosorbent Assay
Phenotype
Control Groups

Keywords

  • Atherosclerosis
  • Cytokines
  • Ischemic heart diseases
  • T Lymphocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease. / Mazzone, A.; De Servi, S.; Vezzoli, M.; Fossati, G.; Mazzucchelli, I.; Gritti, D.; Ottini, E.; Mussini, A.; Specchia, G.

In: Atherosclerosis, Vol. 145, No. 2, 1999, p. 369-374.

Research output: Contribution to journalArticle

Mazzone, A, De Servi, S, Vezzoli, M, Fossati, G, Mazzucchelli, I, Gritti, D, Ottini, E, Mussini, A & Specchia, G 1999, 'Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease', Atherosclerosis, vol. 145, no. 2, pp. 369-374. https://doi.org/10.1016/S0021-9150(99)00104-5
Mazzone, A. ; De Servi, S. ; Vezzoli, M. ; Fossati, G. ; Mazzucchelli, I. ; Gritti, D. ; Ottini, E. ; Mussini, A. ; Specchia, G. / Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease. In: Atherosclerosis. 1999 ; Vol. 145, No. 2. pp. 369-374.
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AU - Ottini, E.

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