Plasma levels of matrix metalloproteinase-9 in chronic urticaria patients correlate with disease severity and C-reactive protein but not with circulating histamine-releasing factors

A. Tedeschi, R. Asero, M. Lorini, A. V. Marzano, M. Cugno

Research output: Contribution to journalArticle

Abstract

Summary Background Matrix metalloproteinase-9 (MMP-9) is an endopeptidase produced by many inflammatory cells that has been found in increased amounts in plasma from patients with chronic urticaria (CU). Objective To evaluate plasma levels of MMP-9 and its tissue inhibitor of metalloproteinase-1 (TIMP-1) in CU patients in relation with disease severity, C-reactive protein (CRP) and circulating histamine-releasing factors. Methods Fifty-two consecutive CU patients were included in the study and disease activity was graded from 0 to 3. Plasma MMP-9, TIMP-1 and CRP levels were measured by enzyme immunoassays. Circulating histamine-releasing factors were assessed using in vivo (autologous serum skin test) and in vitro (basophil histamine release) tests. Seven CU patients were studied both during active disease and during remission. Thirty healthy subjects were used as normal controls. Results Plasma levels of MMP-9, TIMP-1 and CRP were significantly higher in CU patients than in healthy controls (P=0.0001, 0.003 and 0.005, respectively) and a trend towards a higher MMP-9/TIMP-1 molar ratio was found (P=0.051). A significant correlation was found between plasma MMP-9 levels and urticaria severity score (r=0.48, P

Original languageEnglish
Pages (from-to)875-881
Number of pages7
JournalClinical and Experimental Allergy
Volume40
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Autologous serum skin test
  • C-reactive protein
  • Chronic urticaria
  • Histamine-releasing factors
  • Matrix metalloproteinase-9
  • Tissue inhibitor of metalloproteinase-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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