Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment

G. Sangiorgi, R. D'Averio, A. Mauriello, M. Bondio, M. Pontillo, S. Castelvecchio, S. Trimarchi, V. Tolva, G. Nano, V. Rampoldi, L. Giusto, L. S. Inglese

Research output: Contribution to journalArticle

Abstract

Background - Structural alterations of aortic wall resulting from degradation of matrix proteins by matrix metalloproteinases (MMPs) characterize abdominal aortic aneurysms (AAAs). No studies have compared circulating levels of MMPs after endovascular graft (EVG) exclusion in comparison with open surgical repair (OSR) in patients affected by AAA. Methods and Results - An abdominal angiography and CT scan were performed in all patients at the time of enrollment. A spiral CT scan was performed at 6 months to detect presence of endoleaks. MMP-3 and MMP-9 levels were measured before EVG (n=30) and OSR (n=15) treatments and at 1, 3, and 6 months of follow-up by a sandwich ELISA technique. Healthy volunteers (n=10) were used as control subjects. Immunohistochemical staining for MMP-9 and MMP-3 was performed on tissue samples from surgical cases. Both MMP-9 and MMP-3 mean basal levels were significantly higher in patients affected by AAA than in control subjects (32.3±20.7 ng/mL for EVG and 28±9.9 ng/mL for OSR versus 8.9±2.5 ng/mL, 2P

Original languageEnglish
JournalCirculation
Volume104
Issue numberSUPPL. 1
Publication statusPublished - Sep 18 2001

Keywords

  • Aneurysm
  • Metalloproteinases
  • Peripheral vascular disease

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment'. Together they form a unique fingerprint.

  • Cite this

    Sangiorgi, G., D'Averio, R., Mauriello, A., Bondio, M., Pontillo, M., Castelvecchio, S., Trimarchi, S., Tolva, V., Nano, G., Rampoldi, V., Giusto, L., & Inglese, L. S. (2001). Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment. Circulation, 104(SUPPL. 1).