Abstract
Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.
| Original language | Italian |
|---|---|
| Pages (from-to) | 383-385 |
| Number of pages | 3 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Volume | NO. 45-46 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Clinical Neurology
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COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO. / Franceschi, M.; Perego, L.; Mamoli, A.
In: Bollettino - Lega Italiana contro l'Epilessia, Vol. NO. 45-46, 1984, p. 383-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO
AU - Franceschi, M.
AU - Perego, L.
AU - Mamoli, A.
PY - 1984
Y1 - 1984
N2 - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.
AB - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021670106&partnerID=8YFLogxK
M3 - Articolo
VL - NO. 45-46
SP - 383
EP - 385
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
ER -