COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO

M. Franceschi; L. Perego; A. Mamoli

COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO

Translated title of the contribution: Plasma levels of parathyroid hormone, calcitonin and vitamin D in epileptics without ostemalacia on long-term anticonvulsive therapy

M. Franceschi, L. Perego, A. Mamoli

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

Translated title of the contribution	Plasma levels of parathyroid hormone, calcitonin and vitamin D in epileptics without ostemalacia on long-term anticonvulsive therapy
Original language	Italian
Pages (from-to)	383-385
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Volume	NO. 45-46
Publication status	Published - 1984

ASJC Scopus subject areas

Clinical Neurology

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@article{2adcb2efeab840b1b790ae9fa8f55208,

title = "COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO",

abstract = "Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.",

author = "M. Franceschi and L. Perego and A. Mamoli",

year = "1984",

language = "Italian",

volume = "NO. 45-46",

pages = "383--385",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

issn = "0394-560X",

publisher = "Lega Italiana contro l'Epilessia",

}

TY - JOUR

T1 - COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO

AU - Franceschi, M.

AU - Perego, L.

AU - Mamoli, A.

PY - 1984

Y1 - 1984

N2 - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

AB - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

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M3 - Articolo

AN - SCOPUS:0021670106

VL - NO. 45-46

SP - 383

EP - 385

JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

SN - 0394-560X

ER -