COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO

Translated title of the contribution: Plasma levels of parathyroid hormone, calcitonin and vitamin D in epileptics without ostemalacia on long-term anticonvulsive therapy

M. Franceschi, L. Perego, A. Mamoli

Research output: Contribution to journalArticle

Abstract

Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

Original languageItalian
Pages (from-to)383-385
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
VolumeNO. 45-46
Publication statusPublished - 1984

Fingerprint

Calcitonin
Parathyroid Hormone
Vitamin D
Osteomalacia
Seizures
Therapeutics
Anticonvulsants
Neurotransmitter Agents
Calcium

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO. / Franceschi, M.; Perego, L.; Mamoli, A.

In: Bollettino - Lega Italiana contro l'Epilessia, Vol. NO. 45-46, 1984, p. 383-385.

Research output: Contribution to journalArticle

@article{2adcb2efeab840b1b790ae9fa8f55208,
title = "COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO",
abstract = "Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30{\%} of epileptics on polytherapy and in 25{\%} of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.",
author = "M. Franceschi and L. Perego and A. Mamoli",
year = "1984",
language = "Italian",
volume = "NO. 45-46",
pages = "383--385",
journal = "Bollettino - Lega Italiana contro l'Epilessia",
issn = "0394-560X",
publisher = "Lega Italiana contro l'Epilessia",

}

TY - JOUR

T1 - COMPORTAMENTO DEL PARATORMONE, DELLA CALCITONINA E DELLA VITAMINA D IN PAZIENTI CON EPILESSIA SENZA OSTEOMALACIA IN TRATTAMENTO CRONICO FARMACOLOGICO

AU - Franceschi, M.

AU - Perego, L.

AU - Mamoli, A.

PY - 1984

Y1 - 1984

N2 - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

AB - Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.

UR - http://www.scopus.com/inward/record.url?scp=0021670106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021670106&partnerID=8YFLogxK

M3 - Articolo

VL - NO. 45-46

SP - 383

EP - 385

JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

SN - 0394-560X

ER -