Osteomalacia caused by antiepileptic drugs is usually attributed to vit. D (25OHD) deficiency, but too little is known about parathyroid hormone (PTH) and calcitonin (CT), both major calcium regulators and putative neuromodulators. We studied 38 epileptics without signs of osteomalacia and with normal 25OHD plasma levels. PTH and CT plasma levels were assayed with RIA techniques on blood samples taken in a seizures-free day on 8,12 a.m. and 6,12 p.m. In 12 epileptics blood samples were also taken immediately after a convulsive seizure. 78 untreated non-epileptics were controls. 25OHD plasma levels inversely correlated with duration of therapy. Post-seizure PTH levels were significantly reduced, PTH and CT levels were increased in 30% of epileptics on polytherapy and in 25% of epileptics on CBZ, respectively. On the whole, however, PTH and CT plasma levels in epileptics are not abnormal.
|Translated title of the contribution||Plasma levels of parathyroid hormone, calcitonin and vitamin D in epileptics without ostemalacia on long-term anticonvulsive therapy|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Clinical Neurology