Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisis

Erfan Nur, Eduard J. van Beers, Shuena Martina, Ivan Cuccovillo, Hans Martin Otten, John John B Schnog, Joost C M Meijers, Alberto Mantovani, Dees P. Brandjes, Barbara Bottazzi, Bart J. Biemond

Research output: Contribution to journalArticlepeer-review


The painful crisis accounts for the majority of sickle cell disease (SCD) related hospital admissions. The prototypic long pentraxin 3 (PTX3), an acute phase protein, is elevated in patients with inflammatory and ischemic states. As the sickle cell painful crisis is associated with both inflammation and tissue ischemia, we questioned whether plasma PTX3 levels are increased during and associated with painful crisis severity. Furthermore, since PTX3 up-regulates endothelial expression of tissue factor we studied PTX levels in relation to markers of endothelial and coagulation activation. Plasma levels of PTX3, ultra-sensitive C-reactive protein (US-CRP), prothrombin fragment 1+2, thrombin-antithrombin (TAT) complexes, von Willebrand Factor antigen and soluble vascular adhesion molecule-1 were determined in 105 asymptomatic sickle cell patients, 33 patients during painful crisis and 30 race matched healthy controls. Plasma PTX3 levels were comparable between patients in asymptomatic state and healthy controls, but significantly higher during painful crisis (Ps=0.43; P=0.013), whereas US-CRP levels did not. PTX3 levels did not correlate with markers of hypercoagulability. The increase of PTX3 levels during painful crisis and their relation to the duration of subsequent hospital stay suggest that PTX3 might serve both as a diagnostic and severity marker of the painful sickle cell crisis.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalBlood cells, molecules & diseases
Issue number3
Publication statusPublished - Mar 15 2011


  • Ischemia
  • Painful crisis
  • Pentraxin-3
  • Sickle cell disease

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology


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