Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma

A hospital-based case-control study

and, Brescia Melanoma-PCB Working Group

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case–control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95% CI: 0.34–1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95% CI: 1.91–4.73), cumulative lifetime UV exposure (OR = 2.56; 95% CI: 1.35–4.85) and high level of education (OR = 1.45; 95% CI: 1.03–2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalEnvironment International
Volume113
DOIs
Publication statusPublished - Apr 1 2018

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PCB
plasma
hospital
cancer
skin
exposure

Keywords

  • Environmental risk factors
  • Melanoma
  • Polychlorinated biphenyls

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma : A hospital-based case-control study. / and; Brescia Melanoma-PCB Working Group.

In: Environment International, Vol. 113, 01.04.2018, p. 20-25.

Research output: Contribution to journalArticle

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abstract = "Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case–control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95{\%} CI: 0.34–1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95{\%} CI: 1.91–4.73), cumulative lifetime UV exposure (OR = 2.56; 95{\%} CI: 1.35–4.85) and high level of education (OR = 1.45; 95{\%} CI: 1.03–2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population.",
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AU - Donato, Francesco

AU - Manganoni, Ausilia

AU - Comba, Pietro

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AU - Speziani, Fabrizio

AU - Leonardi, Lucia

AU - Orizio, Grazia

AU - Scarcella, Carmelo

AU - Calzavara Pinton, Piergiacomo

AU - Terraroli, Carmen

AU - Coniglio, Arianna

AU - Zarattini, Guido

AU - Manca, Giorgio

AU - Fostinelli, Jacopo

AU - Festa, Roberto

AU - Conti, Maria

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AB - Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case–control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95% CI: 0.34–1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95% CI: 1.91–4.73), cumulative lifetime UV exposure (OR = 2.56; 95% CI: 1.35–4.85) and high level of education (OR = 1.45; 95% CI: 1.03–2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population.

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