Abstract
A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2-30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions.
| Original language | English |
|---|---|
| Pages (from-to) | 317-327 |
| Number of pages | 11 |
| Journal | Clinica Chimica Acta |
| Volume | 130 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 15 1983 |
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ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
Cite this
Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency. / Catapano, Alberico L.; Mills, Gervase L.; Roma, P.; La Rosa, Mario; Capurso, Antonio.
In: Clinica Chimica Acta, Vol. 130, No. 3, 15.06.1983, p. 317-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency
AU - Catapano, Alberico L.
AU - Mills, Gervase L.
AU - Roma, P.
AU - La Rosa, Mario
AU - Capurso, Antonio
PY - 1983/6/15
Y1 - 1983/6/15
N2 - A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2-30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions.
AB - A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2-30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020575357&partnerID=8YFLogxK
U2 - 10.1016/0009-8981(83)90306-6
DO - 10.1016/0009-8981(83)90306-6
M3 - Article
C2 - 6872264
AN - SCOPUS:0020575357
VL - 130
SP - 317
EP - 327
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 3
ER -