Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency

Alberico L. Catapano, Gervase L. Mills, P. Roma, Mario La Rosa, Antonio Capurso

Research output: Contribution to journalArticlepeer-review

Abstract

A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2-30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalClinica Chimica Acta
Volume130
Issue number3
DOIs
Publication statusPublished - Jun 15 1983

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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