Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency

Alberico L. Catapano, Gervase L. Mills, P. Roma, Mario La Rosa, Antonio Capurso

Research output: Contribution to journalArticle

Abstract

A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2-30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalClinica Chimica Acta
Volume130
Issue number3
DOIs
Publication statusPublished - Jun 15 1983

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Apolipoprotein C-II
Apoproteins
Lipoproteins
Lipids
Plasmas
Triglycerides
Immunochemistry
Chylomicrons
VLDL Lipoproteins
Lipoprotein Lipase
Isoelectric Focusing
HDL Lipoproteins
Electrophoresis
LDL Lipoproteins
HDL Cholesterol
Gels

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency. / Catapano, Alberico L.; Mills, Gervase L.; Roma, P.; La Rosa, Mario; Capurso, Antonio.

In: Clinica Chimica Acta, Vol. 130, No. 3, 15.06.1983, p. 317-327.

Research output: Contribution to journalArticle

Catapano, Alberico L. ; Mills, Gervase L. ; Roma, P. ; La Rosa, Mario ; Capurso, Antonio. / Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency. In: Clinica Chimica Acta. 1983 ; Vol. 130, No. 3. pp. 317-327.
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