Plasma lipoprotein(a) levels in subjects attending a metabolic ward: Discrimination between individuals with and without a history of ischemic stroke

Maurizio Margaglione, Giovanni DiMinno, Elvira Grandone, Egidio Celentano, Gennaro Vecchione, Giuseppe Cappucci, Massimo Grilli, Francesco Paolo Mancini, Alfredo Postiglione, Salvatore Panico, Mario Mancini

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Abstract

In this cross-sectional study we compared the abilities of lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI- 1), and tissue plasminogen activator (TPA) to discriminate between individuals with and without a history of stroke from among subjects in a metabolic ward. A total of 210 subjects (108 men and 102 women: mean age, 63.8 years; range, 31 to 86 years) provided plasma and DNA samples for the study. Of these, 51 men and 50 women had a history of ischemia stroke. The 109 subjects without a history of stroke were compared with those with such a history for major risk factors for ischemic events. Mean plasma TPA and PAI- 1 levels significantly (P50 mg/dL were more common among stroke patients (8 with versus 1 without, P2 test). A molecular variation in the 5' flanking region of the apo(a) gene that has been related to elevated Lp(a) plasma levels (G/A-914) was not strongly correlated with circulating levels of Lp(a), nor did Lp(a) levels correlate with a polymorphism of the apo(a) gene (G/A-21), which is strongly linked (P50 mg/dL) plasma levels of the lipoprotein.

Original languageEnglish
Pages (from-to)120-128
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume16
Issue number1
Publication statusPublished - 1996

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Keywords

  • fibrinolytic variables
  • genotype
  • ischemic stroke
  • lipoprotein(a)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Margaglione, M., DiMinno, G., Grandone, E., Celentano, E., Vecchione, G., Cappucci, G., Grilli, M., Mancini, F. P., Postiglione, A., Panico, S., & Mancini, M. (1996). Plasma lipoprotein(a) levels in subjects attending a metabolic ward: Discrimination between individuals with and without a history of ischemic stroke. Arteriosclerosis, Thrombosis, and Vascular Biology, 16(1), 120-128.