TY - JOUR
T1 - Plasma membrane-associated platforms
T2 - Dynamic scaffolds that organize membrane-associated events
AU - Astro, Veronica
AU - De Curtis, Ivan
PY - 2015/3/10
Y1 - 2015/3/10
N2 - Specialized regions of the plasma membrane dedicated to diverse cellular processes, such as vesicle exocytosis, extracellular matrix remodeling, and cell migration, share a few cytosolic scaffold proteins that associate to form large plasma membrane-associated platforms (PMAPs). PMAPs organize signaling events and trafficking of membranes and molecules at specific membrane domains. On the basis of the intrinsic disorder of the proteins constituting the core of these PMAPs and of the dynamics of these structures at the periphery of motile cells, we propose a working model for the assembly and turnover of these platforms.
AB - Specialized regions of the plasma membrane dedicated to diverse cellular processes, such as vesicle exocytosis, extracellular matrix remodeling, and cell migration, share a few cytosolic scaffold proteins that associate to form large plasma membrane-associated platforms (PMAPs). PMAPs organize signaling events and trafficking of membranes and molecules at specific membrane domains. On the basis of the intrinsic disorder of the proteins constituting the core of these PMAPs and of the dynamics of these structures at the periphery of motile cells, we propose a working model for the assembly and turnover of these platforms.
UR - http://www.scopus.com/inward/record.url?scp=84930507915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930507915&partnerID=8YFLogxK
U2 - 10.1126/scisignal.aaa3312
DO - 10.1126/scisignal.aaa3312
M3 - Article
C2 - 25759479
AN - SCOPUS:84930507915
VL - 8
JO - Science Signaling
JF - Science Signaling
SN - 1937-9145
IS - 367
M1 - re1
ER -