Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration

M. Breda, M. Bianchi, C. Ripamonti, E. Zecca, V. Ventafridda, A. E. Panerai

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical studies on the effectiveness of morphine administered through different routes are contradictory. In order to further elucidate this point, the plasma concentrations of morphine and its 3- and 6-glucuronated metabolites were measured after short-term oral, sublabial, rectal and subcutaneous administration of the opiate. The bioavailability of free morphine and the 6-glucuronated active metabolite was comparable through the different routes. It was concluded that the choice of the route of morphine administration should be mainly guided by the needs of each individual patient.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalInternational Journal of Clinical Pharmacology Research
Volume11
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration'. Together they form a unique fingerprint.

Cite this