Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-heart failure trial: Relation with fish intake, circulating biomarkers, and mortality

Serge Masson, Roberto Marchioli, Dariush Mozaffarian, Roberto Bernasconi, Valentina Milani, Luana Dragani, Mariateresa Tacconi, Rosa Maria Marfisi, Luisa Borgese, Vincenzo Cirrincione, Oreste Febo, Enrico Nicolis, Aldo P. Maggioni, Gianni Tognoni, Luigi Tavazzi, Roberto Latini

Research output: Contribution to journalArticle

Abstract

Treatment with long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) can improve clinical outcomes in patients with heart failure (HF). Circulating levels of n-3 PUFA, an objective estimation of exposure, have never been measured in a large cohort of patients with HF. Methods: We measured n-3 PUFA in plasma phospholipids at baseline and after 3 months in 1,203 patients with chronic HF enrolled in the GISSI-Heart Failure trial and randomized to n-3 PUFA 1 g/daily or placebo. N-3 PUFA levels were related to clinical characteristics, pharmacologic treatments, dietary habits, circulating biomarkers, and mortality. Results: Baseline n-3 PUFA (5.1 ± 1.8 mol%) was associated with dietary fish intake, with an average difference of 43% between patients with the lowest and highest consumptions (P

Original languageEnglish
JournalAmerican Heart Journal
Volume165
Issue number2
DOIs
Publication statusPublished - Feb 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Masson, S., Marchioli, R., Mozaffarian, D., Bernasconi, R., Milani, V., Dragani, L., Tacconi, M., Marfisi, R. M., Borgese, L., Cirrincione, V., Febo, O., Nicolis, E., Maggioni, A. P., Tognoni, G., Tavazzi, L., & Latini, R. (2013). Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-heart failure trial: Relation with fish intake, circulating biomarkers, and mortality. American Heart Journal, 165(2). https://doi.org/10.1016/j.ahj.2012.10.021