Plasma osteoprotegerin as a biochemical marker for vascular dementia and Alzheimer's disease.

Enzo Emanuele, Emmanouil Peros, Giuseppe A. Scioli, Angela D'Angelo, Carlo Olivieri, Lorenza Montagna, Diego Geroldi

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated level of osteoprotegerin (OPG), a pleiotropic cytokine involved in bone metabolism, has been associated with coronary heart disease and higher cardiovascular mortality. Because cardiovascular disorders are recognized risk factors for dementia, the study of OPG as a disease marker in vascular dementia (VaD) and Alzheimer's disease (AD) seemed worthy of investigation. OPG concentration was determined by ELISA in an Italian cohort consisting of 39 VaD patients, 36 AD patients, and 39 non-demented controls strictly matched for age and gender. Plasma OPG levels were positively related to age in both demented and non-demented persons. OPG concentrations were significantly higher in both VaD (median: 4.75 pmol/l; interquartile range: 3.42-6.85 pmol/l; P

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalInternational Journal of Molecular Medicine
Volume13
Issue number6
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Genetics

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