Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension

Paolo Manunta; Elisabetta Messaggio; Cinzia Ballabeni; Maria Teresa Sciarrone; Chiara Lanzani; Mara Ferrandi; John M. Hamlyn; Daniele Cusi; Ferruccio Galletti; Giuseppe Bianchi

Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension

Paolo Manunta, Elisabetta Messaggio, Cinzia Ballabeni, Maria Teresa Sciarrone, Chiara Lanzani, Mara Ferrandi, John M. Hamlyn, Daniele Cusi, Ferruccio Galletti, Giuseppe Bianchi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. However, the response of plasma ouabain-like factor to acute and chronic variation of body sodium is unclear. We studied 138 patients with essential hypertension who underwent an acute volume expansion/contraction maneuver (2 days) and 20 patients who entered a blind randomized crossover design involving chronically controlled sodium intake and depletion (170 to 70 mmol/d; 2 weeks each period). In both studies, plasma levels of ouabain-like factor were higher during sodium depletion (acute: 338.8±17.4 and 402.7±22.8 pmol/L for baseline and low sodium, respectively, P

Original language	English
Pages (from-to)	198-203
Number of pages	6
Journal	Hypertension
Volume	38
Issue number	2
Publication status	Published - 2001

Keywords

Endogenous
High blood pressure
Salt sensitivity
Sodium pump inhibitor

ASJC Scopus subject areas

Internal Medicine

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Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension. / Manunta, Paolo; Messaggio, Elisabetta; Ballabeni, Cinzia; Sciarrone, Maria Teresa; Lanzani, Chiara; Ferrandi, Mara; Hamlyn, John M.; Cusi, Daniele; Galletti, Ferruccio; Bianchi, Giuseppe.

In: Hypertension, Vol. 38, No. 2, 2001, p. 198-203.

Research output: Contribution to journal › Article › peer-review

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