Abstract
An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. However, the response of plasma ouabain-like factor to acute and chronic variation of body sodium is unclear. We studied 138 patients with essential hypertension who underwent an acute volume expansion/contraction maneuver (2 days) and 20 patients who entered a blind randomized crossover design involving chronically controlled sodium intake and depletion (170 to 70 mmol/d; 2 weeks each period). In both studies, plasma levels of ouabain-like factor were higher during sodium depletion (acute: 338.8±17.4 and 402.7±22.8 pmol/L for baseline and low sodium, respectively, P
Original language | English |
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Pages (from-to) | 198-203 |
Number of pages | 6 |
Journal | Hypertension |
Volume | 38 |
Issue number | 2 |
Publication status | Published - 2001 |
Keywords
- Endogenous
- High blood pressure
- Salt sensitivity
- Sodium pump inhibitor
ASJC Scopus subject areas
- Internal Medicine