Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension

Paolo Manunta, Elisabetta Messaggio, Cinzia Ballabeni, Maria Teresa Sciarrone, Chiara Lanzani, Mara Ferrandi, John M. Hamlyn, Daniele Cusi, Ferruccio Galletti, Giuseppe Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. However, the response of plasma ouabain-like factor to acute and chronic variation of body sodium is unclear. We studied 138 patients with essential hypertension who underwent an acute volume expansion/contraction maneuver (2 days) and 20 patients who entered a blind randomized crossover design involving chronically controlled sodium intake and depletion (170 to 70 mmol/d; 2 weeks each period). In both studies, plasma levels of ouabain-like factor were higher during sodium depletion (acute: 338.8±17.4 and 402.7±22.8 pmol/L for baseline and low sodium, respectively, P

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalHypertension
Volume38
Issue number2
Publication statusPublished - 2001

Keywords

  • Endogenous
  • High blood pressure
  • Salt sensitivity
  • Sodium pump inhibitor

ASJC Scopus subject areas

  • Internal Medicine

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