Plasma Oxytocin Concentration in Pre- A nd Postmenopausal Women

Its Relationship with Obesity, Body Composition and Metabolic Variables

Sabrina Maestrini, Chiara Mele, Stefania Mai, Roberta Vietti, Annamaria Di Blasio, Luigi Castello, Daniela Surico, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post-than in premenopausal women (NW: P < 0.05; OB: P < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

Original languageEnglish
Pages (from-to)429-439
Number of pages11
JournalObesity Facts
Volume11
Issue number5
DOIs
Publication statusPublished - Nov 1 2018

Fingerprint

menopause
Oxytocin
Menopause
Body Composition
Obesity
Fats
Adiponectin
Leptin
Homeostasis
Lipids
Weights and Measures
Group
Adiposity
study group
Gonadotropins
Longitudinal Studies
longitudinal study
Cross-Sectional Studies
Steroids
Glucose

Keywords

  • Body composition
  • Menopause
  • Obesity
  • Oxytocin

ASJC Scopus subject areas

  • Health(social science)
  • Physiology (medical)

Cite this

Plasma Oxytocin Concentration in Pre- A nd Postmenopausal Women : Its Relationship with Obesity, Body Composition and Metabolic Variables. / Maestrini, Sabrina; Mele, Chiara; Mai, Stefania; Vietti, Roberta; Di Blasio, Annamaria; Castello, Luigi; Surico, Daniela; Aimaretti, Gianluca; Scacchi, Massimo; Marzullo, Paolo.

In: Obesity Facts, Vol. 11, No. 5, 01.11.2018, p. 429-439.

Research output: Contribution to journalArticle

@article{d8ade70f02eb4b338b0031fbbe1fce16,
title = "Plasma Oxytocin Concentration in Pre- A nd Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables",
abstract = "Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass ({\%}FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and {\%}FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post-than in premenopausal women (NW: P < 0.05; OB: P < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.",
keywords = "Body composition, Menopause, Obesity, Oxytocin",
author = "Sabrina Maestrini and Chiara Mele and Stefania Mai and Roberta Vietti and {Di Blasio}, Annamaria and Luigi Castello and Daniela Surico and Gianluca Aimaretti and Massimo Scacchi and Paolo Marzullo",
year = "2018",
month = "11",
day = "1",
doi = "10.1159/000492001",
language = "English",
volume = "11",
pages = "429--439",
journal = "Obesity Facts",
issn = "1662-4025",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Plasma Oxytocin Concentration in Pre- A nd Postmenopausal Women

T2 - Its Relationship with Obesity, Body Composition and Metabolic Variables

AU - Maestrini, Sabrina

AU - Mele, Chiara

AU - Mai, Stefania

AU - Vietti, Roberta

AU - Di Blasio, Annamaria

AU - Castello, Luigi

AU - Surico, Daniela

AU - Aimaretti, Gianluca

AU - Scacchi, Massimo

AU - Marzullo, Paolo

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post-than in premenopausal women (NW: P < 0.05; OB: P < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

AB - Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post-than in premenopausal women (NW: P < 0.05; OB: P < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

KW - Body composition

KW - Menopause

KW - Obesity

KW - Oxytocin

UR - http://www.scopus.com/inward/record.url?scp=85056132613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056132613&partnerID=8YFLogxK

U2 - 10.1159/000492001

DO - 10.1159/000492001

M3 - Article

VL - 11

SP - 429

EP - 439

JO - Obesity Facts

JF - Obesity Facts

SN - 1662-4025

IS - 5

ER -