Plasma pepsinogens, nutrients, and diet in areas of italy at varying gastric cancer risk

Domenico Palli; Adriano Decarli; Francesco Cipriani; David Forman; Dino Amadori; Claudio Avellini; Attilio Giacosa; Pierina Manca; Antonio Russo; Richard M. Salkeld; I. Michael Samloff; Joseph F. Fraumeni; William J. Blot; Eva Buiatti

Plasma pepsinogens, nutrients, and diet in areas of italy at varying gastric cancer risk

Domenico Palli, Adriano Decarli, Francesco Cipriani, David Forman, Dino Amadori, Claudio Avellini, Attilio Giacosa, Pierina Manca, Antonio Russo, Richard M. Salkeld, I. Michael Samloff, Joseph F. Fraumeni, William J. Blot, Eva Buiatti

Research output: Contribution to journal › Article › peer-review

Abstract

In a survey of 930 adults aged 35-74 years randomly sampled from the general population of four areas of Italy at different risks for gastric cancer (GC), plasma levels of pepsinogens (PGI and PGII) and fat-soluble vitamins were assayed. Pepsinogen levels were used to identify individuals with chronic atrophic gastritis (CAG). Severe CAG (PGI ≤ 20 pg/liter) affected 5.8% of the population, but the prevalence rose with increasing age and declining social class. Severe CAG was 5 times more common in areas with high compared to low rates of GC. Risk also rose with increasing consumption of salted/dried fish but was inversely related to dietary intake of β-carotene and to plasma retinol and cholesterol levels. The prevalence of moderate CAG (PGI > 20 pg/liter, but PGI/PGII ≤ 2.9) was 6.3%. Moderate CAG was also related to age and social class and increased 1.8-fold in areas where GC rates were high, but was not strongly associated with diet or plasma nutrients. The authors discuss these findings in relation to those from a previous casecontrol study of GC in the same areas.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	1
Issue number	1
Publication status	Published - 1991

ASJC Scopus subject areas

Epidemiology
Oncology

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Plasma pepsinogens, nutrients, and diet in areas of italy at varying gastric cancer risk. / Palli, Domenico; Decarli, Adriano; Cipriani, Francesco; Forman, David; Amadori, Dino; Avellini, Claudio; Giacosa, Attilio; Manca, Pierina; Russo, Antonio; Salkeld, Richard M.; Samloff, I. Michael; Fraumeni, Joseph F.; Blot, William J.; Buiatti, Eva.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 1, No. 1, 1991, p. 45-50.

Research output: Contribution to journal › Article › peer-review

Palli, Domenico ; Decarli, Adriano ; Cipriani, Francesco ; Forman, David ; Amadori, Dino ; Avellini, Claudio ; Giacosa, Attilio ; Manca, Pierina ; Russo, Antonio ; Salkeld, Richard M. ; Samloff, I. Michael ; Fraumeni, Joseph F. ; Blot, William J. ; Buiatti, Eva. / Plasma pepsinogens, nutrients, and diet in areas of italy at varying gastric cancer risk. In: Cancer Epidemiology Biomarkers and Prevention. 1991 ; Vol. 1, No. 1. pp. 45-50.

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abstract = "In a survey of 930 adults aged 35-74 years randomly sampled from the general population of four areas of Italy at different risks for gastric cancer (GC), plasma levels of pepsinogens (PGI and PGII) and fat-soluble vitamins were assayed. Pepsinogen levels were used to identify individuals with chronic atrophic gastritis (CAG). Severe CAG (PGI ≤ 20 pg/liter) affected 5.8% of the population, but the prevalence rose with increasing age and declining social class. Severe CAG was 5 times more common in areas with high compared to low rates of GC. Risk also rose with increasing consumption of salted/dried fish but was inversely related to dietary intake of β-carotene and to plasma retinol and cholesterol levels. The prevalence of moderate CAG (PGI > 20 pg/liter, but PGI/PGII ≤ 2.9) was 6.3%. Moderate CAG was also related to age and social class and increased 1.8-fold in areas where GC rates were high, but was not strongly associated with diet or plasma nutrients. The authors discuss these findings in relation to those from a previous casecontrol study of GC in the same areas.",

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AU - Avellini, Claudio

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AU - Manca, Pierina

AU - Russo, Antonio

AU - Salkeld, Richard M.

AU - Samloff, I. Michael

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AU - Blot, William J.

AU - Buiatti, Eva

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