Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Véronique Chajès, Mazda Jenab, Isabelle Romieu, Pietro Ferrari, Christina C. Dahm, Kim Overvad, Rikke Egeberg, Anne Tjønneland, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Pierre Engel, Birgit Teucher, Rudolf Kaaks, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Vardis Dilis, Tina Karapetyan, Amalia Mattiello, Rosario Tumino & 24 others Sara Grioni, Domenico Palli, Paolo Vineis, H. Bas Bueno-de-Mesquita, Mattijs E. Numans, Petra H M Peeters, Eiliv Lund, Carmen Navarro, Jose Ramón Quirós, Emilio Sánchez-Cantalejo, Aurelio Barricarte Gurrea, Miren Dorronsoro, Sara Regnér, Emily Sonestedt, Elisabet Wirfält, Kay Tee Khaw, Nick Wareham, Naomi E. Allen, Francesca L. Crowe, Sabina Rinaldi, Nadia Slimani, Fatima Carneiro, Elio Riboli, Carlos A. González

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.

Original languageEnglish
Pages (from-to)1304-1313
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number5
DOIs
Publication statusPublished - Nov 1 2011

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Stomach Neoplasms
alpha-Linolenic Acid
Phospholipids
Stomach
Adenocarcinoma
Fatty Acids
Neoplasms
Oleic Acid
Logistic Models
Stearoyl-CoA Desaturase
Physical Education and Training
Helicobacter Infections
Energy Intake
Blood Donors
Helicobacter pylori
Gas Chromatography
Case-Control Studies
Biomarkers
Smoking
Exercise

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). / Chajès, Véronique; Jenab, Mazda; Romieu, Isabelle; Ferrari, Pietro; Dahm, Christina C.; Overvad, Kim; Egeberg, Rikke; Tjønneland, Anne; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Engel, Pierre; Teucher, Birgit; Kaaks, Rudolf; Floegel, Anna; Boeing, Heiner; Trichopoulou, Antonia; Dilis, Vardis; Karapetyan, Tina; Mattiello, Amalia; Tumino, Rosario; Grioni, Sara; Palli, Domenico; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Numans, Mattijs E.; Peeters, Petra H M; Lund, Eiliv; Navarro, Carmen; Quirós, Jose Ramón; Sánchez-Cantalejo, Emilio; Gurrea, Aurelio Barricarte; Dorronsoro, Miren; Regnér, Sara; Sonestedt, Emily; Wirfält, Elisabet; Khaw, Kay Tee; Wareham, Nick; Allen, Naomi E.; Crowe, Francesca L.; Rinaldi, Sabina; Slimani, Nadia; Carneiro, Fatima; Riboli, Elio; González, Carlos A.

In: American Journal of Clinical Nutrition, Vol. 94, No. 5, 01.11.2011, p. 1304-1313.

Research output: Contribution to journalArticle

Chajès, V, Jenab, M, Romieu, I, Ferrari, P, Dahm, CC, Overvad, K, Egeberg, R, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, MC, Engel, P, Teucher, B, Kaaks, R, Floegel, A, Boeing, H, Trichopoulou, A, Dilis, V, Karapetyan, T, Mattiello, A, Tumino, R, Grioni, S, Palli, D, Vineis, P, Bueno-de-Mesquita, HB, Numans, ME, Peeters, PHM, Lund, E, Navarro, C, Quirós, JR, Sánchez-Cantalejo, E, Gurrea, AB, Dorronsoro, M, Regnér, S, Sonestedt, E, Wirfält, E, Khaw, KT, Wareham, N, Allen, NE, Crowe, FL, Rinaldi, S, Slimani, N, Carneiro, F, Riboli, E & González, CA 2011, 'Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)', American Journal of Clinical Nutrition, vol. 94, no. 5, pp. 1304-1313. https://doi.org/10.3945/ajcn.110.005892
Chajès, Véronique ; Jenab, Mazda ; Romieu, Isabelle ; Ferrari, Pietro ; Dahm, Christina C. ; Overvad, Kim ; Egeberg, Rikke ; Tjønneland, Anne ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Engel, Pierre ; Teucher, Birgit ; Kaaks, Rudolf ; Floegel, Anna ; Boeing, Heiner ; Trichopoulou, Antonia ; Dilis, Vardis ; Karapetyan, Tina ; Mattiello, Amalia ; Tumino, Rosario ; Grioni, Sara ; Palli, Domenico ; Vineis, Paolo ; Bueno-de-Mesquita, H. Bas ; Numans, Mattijs E. ; Peeters, Petra H M ; Lund, Eiliv ; Navarro, Carmen ; Quirós, Jose Ramón ; Sánchez-Cantalejo, Emilio ; Gurrea, Aurelio Barricarte ; Dorronsoro, Miren ; Regnér, Sara ; Sonestedt, Emily ; Wirfält, Elisabet ; Khaw, Kay Tee ; Wareham, Nick ; Allen, Naomi E. ; Crowe, Francesca L. ; Rinaldi, Sabina ; Slimani, Nadia ; Carneiro, Fatima ; Riboli, Elio ; González, Carlos A. / Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). In: American Journal of Clinical Nutrition. 2011 ; Vol. 94, No. 5. pp. 1304-1313.
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abstract = "Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95{\%} CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95{\%} CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95{\%} CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95{\%} CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95{\%} CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.",
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T1 - Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

AU - Chajès, Véronique

AU - Jenab, Mazda

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Egeberg, Rikke

AU - Tjønneland, Anne

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Engel, Pierre

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Floegel, Anna

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Dilis, Vardis

AU - Karapetyan, Tina

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Grioni, Sara

AU - Palli, Domenico

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H. Bas

AU - Numans, Mattijs E.

AU - Peeters, Petra H M

AU - Lund, Eiliv

AU - Navarro, Carmen

AU - Quirós, Jose Ramón

AU - Sánchez-Cantalejo, Emilio

AU - Gurrea, Aurelio Barricarte

AU - Dorronsoro, Miren

AU - Regnér, Sara

AU - Sonestedt, Emily

AU - Wirfält, Elisabet

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Allen, Naomi E.

AU - Crowe, Francesca L.

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Carneiro, Fatima

AU - Riboli, Elio

AU - González, Carlos A.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.

AB - Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST). Design: Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. Results: Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66). Conclusion: These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.

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