Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne U. Jakobsen, Claus Dethlefsen, Karen M. Due, Nadia Slimani, Veronique Chajès, Anne M. May, Thorkild I A Sørensen, Jytte Halkjær, Anne Tjønneland, Francoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico PalliAmalia Mattiello, Giovanna Tagliabue, Daphne L. Van Der A, H. B. Bueno-De-Mesquita, Laudina Rodríguez, Noémie Travier, Esther Molina-Montes, José M. Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Ingegerd Johansson, Göran Hallmans, Kay Tee Khaw, Nicholas J. Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H M Peeters, Kim Overvad

Research output: Contribution to journalArticlepeer-review


Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalObesity Facts
Issue number4
Publication statusPublished - Aug 2011


  • Body weight
  • Cohort study
  • n-3 fatty acids
  • Omega-3 fatty acids
  • Weight change

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)


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