Plasma polyunsaturated fatty acids and the decline of renal function

Fulvio Lauretani, Richard D. Semba, Stefania Bandinelli, Edgar R. Miller, Carmelinda Ruggiero, Antonio Cherubini, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Recent studies suggest an association between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease. The aim of this study was to examine the relationship between PUFAs and renal function in older adults. METHODS: We performed a cross-sectional and prospective analysis of 931 adults, ≥65 years old, enrolled in the InCHIANTI study, a population-based cohort in Tuscany, Italy. Plasma PUFAs were measured at enrollment, and creatinine clearance was estimated by the Cockcroft-Gault equation at baseline and after 3-year follow-up. RESULTS: At enrollment, participants with higher creatinine clearance had higher concentrations of HDL cholesterol, total plasma PUFAs, plasma n-3 fatty acid (FA), and plasma n-6 FA and lower triglycerides. From enrollment to the 3-year follow-up visit, creatinine clearance declined by 7.8 (12.2) mL/min (P

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalClinical Chemistry
Issue number3
Publication statusPublished - Mar 1 2008

ASJC Scopus subject areas

  • Clinical Biochemistry

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