Plasma protein acute-phase response in unstable angina is not induced by ischemic injury

Giovanna Liuzzo, Luigi M. Biasucci, Antonio G. Rebuzzi, J. Ruth Gallimore, Giuseppina Caligiuri, Gaetano A. Lanza, Gaetano Quaranta, Claudia Monaco, Mark B. Pepys, Attilio Maseri

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Background: Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia reperfusion in jury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results: Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients (P 10 minutes. Conclusions: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute- phase response.

Original languageEnglish
Pages (from-to)2373-2380
Number of pages8
JournalCirculation
Volume94
Issue number10
Publication statusPublished - 1996

Fingerprint

Acute-Phase Reaction
Unstable Angina
C-Reactive Protein
Blood Proteins
Wounds and Injuries
Myocardial Ischemia
Coronary Care Units
Ambulatory Electrocardiography
Spasm
Reperfusion
Coronary Vessels
Electrocardiography
Ischemia

Keywords

  • angina
  • inflammation
  • ischemia
  • reperfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Liuzzo, G., Biasucci, L. M., Rebuzzi, A. G., Ruth Gallimore, J., Caligiuri, G., Lanza, G. A., ... Maseri, A. (1996). Plasma protein acute-phase response in unstable angina is not induced by ischemic injury. Circulation, 94(10), 2373-2380.

Plasma protein acute-phase response in unstable angina is not induced by ischemic injury. / Liuzzo, Giovanna; Biasucci, Luigi M.; Rebuzzi, Antonio G.; Ruth Gallimore, J.; Caligiuri, Giuseppina; Lanza, Gaetano A.; Quaranta, Gaetano; Monaco, Claudia; Pepys, Mark B.; Maseri, Attilio.

In: Circulation, Vol. 94, No. 10, 1996, p. 2373-2380.

Research output: Contribution to journalArticle

Liuzzo, G, Biasucci, LM, Rebuzzi, AG, Ruth Gallimore, J, Caligiuri, G, Lanza, GA, Quaranta, G, Monaco, C, Pepys, MB & Maseri, A 1996, 'Plasma protein acute-phase response in unstable angina is not induced by ischemic injury', Circulation, vol. 94, no. 10, pp. 2373-2380.
Liuzzo G, Biasucci LM, Rebuzzi AG, Ruth Gallimore J, Caligiuri G, Lanza GA et al. Plasma protein acute-phase response in unstable angina is not induced by ischemic injury. Circulation. 1996;94(10):2373-2380.
Liuzzo, Giovanna ; Biasucci, Luigi M. ; Rebuzzi, Antonio G. ; Ruth Gallimore, J. ; Caligiuri, Giuseppina ; Lanza, Gaetano A. ; Quaranta, Gaetano ; Monaco, Claudia ; Pepys, Mark B. ; Maseri, Attilio. / Plasma protein acute-phase response in unstable angina is not induced by ischemic injury. In: Circulation. 1996 ; Vol. 94, No. 10. pp. 2373-2380.
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AB - Background: Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia reperfusion in jury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results: Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients (P 10 minutes. Conclusions: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute- phase response.

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