Abstract
Background: Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia reperfusion in jury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results: Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients (P 10 minutes. Conclusions: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute- phase response.
| Original language | English |
|---|---|
| Pages (from-to) | 2373-2380 |
| Number of pages | 8 |
| Journal | Circulation |
| Volume | 94 |
| Issue number | 10 |
| Publication status | Published - 1996 |
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Keywords
- angina
- inflammation
- ischemia
- reperfusion
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Plasma protein acute-phase response in unstable angina is not induced by ischemic injury. / Liuzzo, Giovanna; Biasucci, Luigi M.; Rebuzzi, Antonio G.; Ruth Gallimore, J.; Caligiuri, Giuseppina; Lanza, Gaetano A.; Quaranta, Gaetano; Monaco, Claudia; Pepys, Mark B.; Maseri, Attilio.
In: Circulation, Vol. 94, No. 10, 1996, p. 2373-2380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma protein acute-phase response in unstable angina is not induced by ischemic injury
AU - Liuzzo, Giovanna
AU - Biasucci, Luigi M.
AU - Rebuzzi, Antonio G.
AU - Ruth Gallimore, J.
AU - Caligiuri, Giuseppina
AU - Lanza, Gaetano A.
AU - Quaranta, Gaetano
AU - Monaco, Claudia
AU - Pepys, Mark B.
AU - Maseri, Attilio
PY - 1996
Y1 - 1996
N2 - Background: Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia reperfusion in jury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results: Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients (P 10 minutes. Conclusions: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute- phase response.
AB - Background: Elevated levels of C-reactive protein (CRP) are associated with an unfavorable clinical outcome in patients with unstable angina. To determine whether ischemia reperfusion in jury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. Methods and Results: Blood samples were taken on admission and subsequently at 24, 48, 72, and 96 hours. All patients underwent Holter monitoring for the first 24 hours and remained in the coronary care unit under ECG monitoring until completion of the study. On admission, CRP was significantly higher in unstable angina than in variant angina patients (P 10 minutes. Conclusions: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute- phase response.
KW - angina
KW - inflammation
KW - ischemia
KW - reperfusion
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M3 - Article
C2 - 8921776
AN - SCOPUS:10544253081
VL - 94
SP - 2373
EP - 2380
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 10
ER -