Plasma pyroglutamic acid levels after oral administration of monosodium glutamate to human volunteers

Pietro Ghezzi, Silvio Garattini, Silvio Caccia, Mario Salmona, Maria Grazia Zanini

Research output: Contribution to journalArticle

Abstract

Plasma levels of pyroglutamic (PY) and glutamic (GA) acids have been measured after oral administration of monosodium glutamate (MSG) to 6 human volunteers. MSG (43 mg kg) was administered either after an overnight fast or immediately after a normal meal. In fasting subjects plasma GA peak levels were about 2.3 times the basal levels whereas the increase in plasma PY levels were only 1.5-fold. When MSG was administered with a meal plasma GA levels were raised, to a lesser extent, while no increase could be observed in plasma PY.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalToxicology Letters
Volume15
Issue number2-3
DOIs
Publication statusPublished - 1983

Keywords

  • food additives
  • Monosodium glutamate
  • pyroglutamate

ASJC Scopus subject areas

  • Toxicology

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