Plasma renin activity in primary and secondary depression

A. C. Altamura, A. Morganti, E. Smeraldi, A. Zanchetti

Research output: Contribution to journalArticlepeer-review


Plasma renin activity (PRA), both in supine and standing position, was investigated in primary and secondary depressed patients. After orthostatic stimulation (standing position) primary depressed patients showed PRA values significantly lower than did those with secondary depression. The authors stress the importance of the peripheral sympathetic system in the control of renin release and discuss the data obtained in the light of some evidence in the literature indicating a possible impairment of transmitter turnover in central and peripheral noradrenergic synapses in the pathogenesis of primary depression.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalArchiv für Psychiatrie und Nervenkrankheiten Vereinigt mit Zeitschrift für die Gesamte Neurologie und Psychiatrie
Issue number4
Publication statusPublished - Dec 1977


  • Noradrenergic system
  • Plasma renin activity
  • Primary and secondary depression

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Clinical Neurology
  • Medicine(all)


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