Plasma retinol and prognosis of postmenopausal breast cancer patients

Franca Formelli, Elisabetta Meneghini, Elena Cavadini, Tiziana Camerini, Maria G. Di Mauro, Giuseppe De Palo, Umberto Veronesi, Franco Berrino, Andrea Micheli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The role of retinol (vitamin A) in breast cancer prognosis has never been investigated in postmenopausal women. We prospectively assessed the long-term prognostic role of retinol plasma levels in a cohort of postmenopausal breast cancer patients. Patients and Methods: We investigated 208 women self-reported as postmenopausal operated on for T 1-2N 0M 0 breast cancer who participated in a chemoprevention trial as controls and never received chemotherapy or hormone therapy. Plasma samples were collected 3 months (median) after surgery and assayed within 3 weeks for retinol. Minimum and median potential follow-up were 12 and 15 years, respectively. The main analyses were on all women and on a subgroup ages ≥55 years, assumed too old to be in perimenopause. The main end point was breast cancer death. Breast cancer survival was estimated by the Kaplan-Meier method. The hazard ratios of breast cancer death by retinol level were estimated by Cox models stratified for age, where relevant, and recruitment period, and adjusted for tumor size and histology. Results: At 12 years, patients with low retinol (

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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