Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

A. Handberg, K. Højlund, A. Gastaldelli, A. Flyvbjerg, J. M. Dekker, J. Petrie, P. Piatti, H. Beck-Nielsen

Research output: Contribution to journalArticle

Abstract

Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects. Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic-hyperinsulinaemic clamp, carotid atherosclerosis as intima-media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%). Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2-Q4), whereas adiponectin and M/I decreased (P≤0.01). sCD36 was lower in women than in men (P=0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log-normal distribution (log-normal population, n=1029), sCD36 was increased in subjects with impaired glucose regulation (P=0.045), metabolic syndrome (P=0.006) or increased likelihood of fatty liver (P

Original languageEnglish
Pages (from-to)294-304
Number of pages11
JournalJournal of Internal Medicine
Volume271
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Low-grade inflammation
  • Metabolic syndrome
  • Nonalcoholic fatty liver disease
  • SCD36
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population'. Together they form a unique fingerprint.

  • Cite this