Plasma somatostatin-like immunoreactivity and somatostatin-28 levels in obese men

M. Peracchi, F. Carola, F. Cavagnini, R. Benti, B. Bareggi, G. Baccalaro, G. Basilisco

Research output: Contribution to journalArticlepeer-review

Abstract

Somatostatin (SS) impairs nutrient absorption. It has been suggested that hyposomatostatinaemia may be involved in the pathogenesis of obesity. However, data on postprandial SS-like immunoreactivity (SLI) levels in obese subjects are controversial and the levels of SS-28, the main molecular form of circulating SLI in healthy subjects, have not been determined. To characterise the fasting and postprandial plasma pattern of SLI and SS-28 in obese men, we studied eight obese men (age 24-32 yr, BMI 33-42 kg/m2), with normal glucose tolerance test and normal gastric emptying of solids, and eight healthy men (age 24-39 yr, BMI 21-24 kg/m2). Blood samples were taken at regular intervals in fasting conditions and for 2 h after a standard solid-liquid meal (2.3 MJ). Plasma SLI and SS-28 were measured by RIA. Our results showed that fasting and postprandial plasma SLI and SS-28 levels were not significantly different in healthy and obese subjects. In conclusion SS-28 is the predominant form of circulating SLI in obese subjects. The normal pattern of fasting and postprandial plasma SLI and SS-28 levels in such subjects suggests that somatostatin does not have a pathogenetic role in obesity.

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalJournal of Endocrinological Investigation
Volume21
Issue number1
Publication statusPublished - Jan 1998

Keywords

  • Gastric emptying,
  • Mixed meal
  • Obesity
  • Plasma somatostatin
  • Somatostatin-28

ASJC Scopus subject areas

  • Endocrinology

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