Plasmablastic lymphoma: A review

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large cells with eccentrically located nuclei and deeply basophilic cytoplasm with a paranuclear hof. The tumour cells are invariably immunoreactive for the plasma cell marker CD138, and show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of the Ig light chain (IgL) gene expression in most of the cases. Similar to other types of AIDS-related lymphomas, there is evidence that Epstein-Barr virus and Kaposi-sarcoma associated Human Herpes Virus 8 may play a relevant role in the pathogenesis of PBL. PBL patients have been treated heterogeneously, with a combination of chemotherapy, radiotherapy and/or surgery, and their prognosis is usually poor, with a death rate of approximately 60% at 1 year.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalOral Diseases
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

AIDS-Related Lymphoma
Immunoglobulin Heavy Chain Genes
Kaposi's Sarcoma
Plasma Cells
Combination Drug Therapy
Human Herpesvirus 4
Non-Hodgkin's Lymphoma
Mouth
Cytoplasm
Radiotherapy
HIV
Viruses
Gene Expression
Light
Mortality
Plasmablastic Lymphoma
Neoplasms

Keywords

  • HIV infection
  • Non-Hodgkin's lymphoma
  • Oral cavity
  • Plasma cells
  • Plasmablastic lymphoma

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

Cite this

Plasmablastic lymphoma : A review. / Rafaniello Raviele, P.; Pruneri, G.; Maiorano, E.

In: Oral Diseases, Vol. 15, No. 1, 01.2009, p. 38-45.

Research output: Contribution to journalArticle

Rafaniello Raviele, P. ; Pruneri, G. ; Maiorano, E. / Plasmablastic lymphoma : A review. In: Oral Diseases. 2009 ; Vol. 15, No. 1. pp. 38-45.
@article{e1caec0738c748b8bbf139191fb9bb8f,
title = "Plasmablastic lymphoma: A review",
abstract = "Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large cells with eccentrically located nuclei and deeply basophilic cytoplasm with a paranuclear hof. The tumour cells are invariably immunoreactive for the plasma cell marker CD138, and show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of the Ig light chain (IgL) gene expression in most of the cases. Similar to other types of AIDS-related lymphomas, there is evidence that Epstein-Barr virus and Kaposi-sarcoma associated Human Herpes Virus 8 may play a relevant role in the pathogenesis of PBL. PBL patients have been treated heterogeneously, with a combination of chemotherapy, radiotherapy and/or surgery, and their prognosis is usually poor, with a death rate of approximately 60{\%} at 1 year.",
keywords = "HIV infection, Non-Hodgkin's lymphoma, Oral cavity, Plasma cells, Plasmablastic lymphoma",
author = "{Rafaniello Raviele}, P. and G. Pruneri and E. Maiorano",
year = "2009",
month = "1",
doi = "10.1111/j.1601-0825.2008.01493.x",
language = "English",
volume = "15",
pages = "38--45",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Plasmablastic lymphoma

T2 - A review

AU - Rafaniello Raviele, P.

AU - Pruneri, G.

AU - Maiorano, E.

PY - 2009/1

Y1 - 2009/1

N2 - Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large cells with eccentrically located nuclei and deeply basophilic cytoplasm with a paranuclear hof. The tumour cells are invariably immunoreactive for the plasma cell marker CD138, and show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of the Ig light chain (IgL) gene expression in most of the cases. Similar to other types of AIDS-related lymphomas, there is evidence that Epstein-Barr virus and Kaposi-sarcoma associated Human Herpes Virus 8 may play a relevant role in the pathogenesis of PBL. PBL patients have been treated heterogeneously, with a combination of chemotherapy, radiotherapy and/or surgery, and their prognosis is usually poor, with a death rate of approximately 60% at 1 year.

AB - Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large cells with eccentrically located nuclei and deeply basophilic cytoplasm with a paranuclear hof. The tumour cells are invariably immunoreactive for the plasma cell marker CD138, and show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of the Ig light chain (IgL) gene expression in most of the cases. Similar to other types of AIDS-related lymphomas, there is evidence that Epstein-Barr virus and Kaposi-sarcoma associated Human Herpes Virus 8 may play a relevant role in the pathogenesis of PBL. PBL patients have been treated heterogeneously, with a combination of chemotherapy, radiotherapy and/or surgery, and their prognosis is usually poor, with a death rate of approximately 60% at 1 year.

KW - HIV infection

KW - Non-Hodgkin's lymphoma

KW - Oral cavity

KW - Plasma cells

KW - Plasmablastic lymphoma

UR - http://www.scopus.com/inward/record.url?scp=57549099246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57549099246&partnerID=8YFLogxK

U2 - 10.1111/j.1601-0825.2008.01493.x

DO - 10.1111/j.1601-0825.2008.01493.x

M3 - Article

C2 - 18939960

AN - SCOPUS:57549099246

VL - 15

SP - 38

EP - 45

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 1

ER -