Plasmapheresis in severe forms of myasthenia gravis

Massimo Morosetti, Carlo Meloni, Cesare Iani, Maria Caramia, Cristina Galderisi, Giuditta Palombo, Massimo Taccone Gallucci, Giorgio Bernardi, Carlo Umberto Casciani

Research output: Contribution to journalArticle

Abstract

In this study we introduce a new combination treatment of plasma exchange (PE) and high daily doses of prednisone for severe forms of myasthenia gravis (MG). The clinical efficacy of the combined therapy has been tested in 18 patients suffering from severe forms of MG. The protocol included 5 sessions of PE, performed in a range of 15 days, 1 session every 3 days, with concurrent administration of oral prednisone (1 mg/kg of body weight), starting at the first session of PE and given daily for at least 3 months. At the end of the entire cycle of PE, almost complete recovery (more than 90% of the initial clinical score) was obtained in 8 of 18 patients while an improvement between 60 and 90% of the initial score was achieved in 9 of 18 patients. An early improvement was noted 24 h after the beginning of plasmapheresis in 11 of 18 patients. No recurrence of symptoms was reported after 36 months of follow-up for 17 patients. The administration of steroid therapy was never followed by an early exacerbation of myasthenic symptoms as reported when it is administered in the absence of concomitant PE. According to our results, we can conclude that high doses of oral prednisone therapy in simultaneous association with PE lead to successful control of severe forms of MG, significantly superior to the therapeutic strategies until now adopted and reported in literature.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalArtificial Organs
Volume22
Issue number2
DOIs
Publication statusPublished - 1998

Fingerprint

Plasma Exchange
Plasmapheresis
Myasthenia Gravis
Plasmas
Prednisone
Therapeutics
Muscle Weakness
Oral Administration
Steroids
Body Weight
Recurrence
Recovery

Keywords

  • Myasthenia gravis
  • Myasthenic crisis
  • Plasma exchange
  • Steroids and plasmapheresis
  • Steroids in myasthenia

ASJC Scopus subject areas

  • Biophysics

Cite this

Morosetti, M., Meloni, C., Iani, C., Caramia, M., Galderisi, C., Palombo, G., ... Casciani, C. U. (1998). Plasmapheresis in severe forms of myasthenia gravis. Artificial Organs, 22(2), 129-134. https://doi.org/10.1046/j.1525-1594.1998.05061.x

Plasmapheresis in severe forms of myasthenia gravis. / Morosetti, Massimo; Meloni, Carlo; Iani, Cesare; Caramia, Maria; Galderisi, Cristina; Palombo, Giuditta; Gallucci, Massimo Taccone; Bernardi, Giorgio; Casciani, Carlo Umberto.

In: Artificial Organs, Vol. 22, No. 2, 1998, p. 129-134.

Research output: Contribution to journalArticle

Morosetti, M, Meloni, C, Iani, C, Caramia, M, Galderisi, C, Palombo, G, Gallucci, MT, Bernardi, G & Casciani, CU 1998, 'Plasmapheresis in severe forms of myasthenia gravis', Artificial Organs, vol. 22, no. 2, pp. 129-134. https://doi.org/10.1046/j.1525-1594.1998.05061.x
Morosetti M, Meloni C, Iani C, Caramia M, Galderisi C, Palombo G et al. Plasmapheresis in severe forms of myasthenia gravis. Artificial Organs. 1998;22(2):129-134. https://doi.org/10.1046/j.1525-1594.1998.05061.x
Morosetti, Massimo ; Meloni, Carlo ; Iani, Cesare ; Caramia, Maria ; Galderisi, Cristina ; Palombo, Giuditta ; Gallucci, Massimo Taccone ; Bernardi, Giorgio ; Casciani, Carlo Umberto. / Plasmapheresis in severe forms of myasthenia gravis. In: Artificial Organs. 1998 ; Vol. 22, No. 2. pp. 129-134.
@article{05954c8084954c24adb5a8fa731da5b8,
title = "Plasmapheresis in severe forms of myasthenia gravis",
abstract = "In this study we introduce a new combination treatment of plasma exchange (PE) and high daily doses of prednisone for severe forms of myasthenia gravis (MG). The clinical efficacy of the combined therapy has been tested in 18 patients suffering from severe forms of MG. The protocol included 5 sessions of PE, performed in a range of 15 days, 1 session every 3 days, with concurrent administration of oral prednisone (1 mg/kg of body weight), starting at the first session of PE and given daily for at least 3 months. At the end of the entire cycle of PE, almost complete recovery (more than 90{\%} of the initial clinical score) was obtained in 8 of 18 patients while an improvement between 60 and 90{\%} of the initial score was achieved in 9 of 18 patients. An early improvement was noted 24 h after the beginning of plasmapheresis in 11 of 18 patients. No recurrence of symptoms was reported after 36 months of follow-up for 17 patients. The administration of steroid therapy was never followed by an early exacerbation of myasthenic symptoms as reported when it is administered in the absence of concomitant PE. According to our results, we can conclude that high doses of oral prednisone therapy in simultaneous association with PE lead to successful control of severe forms of MG, significantly superior to the therapeutic strategies until now adopted and reported in literature.",
keywords = "Myasthenia gravis, Myasthenic crisis, Plasma exchange, Steroids and plasmapheresis, Steroids in myasthenia",
author = "Massimo Morosetti and Carlo Meloni and Cesare Iani and Maria Caramia and Cristina Galderisi and Giuditta Palombo and Gallucci, {Massimo Taccone} and Giorgio Bernardi and Casciani, {Carlo Umberto}",
year = "1998",
doi = "10.1046/j.1525-1594.1998.05061.x",
language = "English",
volume = "22",
pages = "129--134",
journal = "Artificial Organs",
issn = "0160-564X",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Plasmapheresis in severe forms of myasthenia gravis

AU - Morosetti, Massimo

AU - Meloni, Carlo

AU - Iani, Cesare

AU - Caramia, Maria

AU - Galderisi, Cristina

AU - Palombo, Giuditta

AU - Gallucci, Massimo Taccone

AU - Bernardi, Giorgio

AU - Casciani, Carlo Umberto

PY - 1998

Y1 - 1998

N2 - In this study we introduce a new combination treatment of plasma exchange (PE) and high daily doses of prednisone for severe forms of myasthenia gravis (MG). The clinical efficacy of the combined therapy has been tested in 18 patients suffering from severe forms of MG. The protocol included 5 sessions of PE, performed in a range of 15 days, 1 session every 3 days, with concurrent administration of oral prednisone (1 mg/kg of body weight), starting at the first session of PE and given daily for at least 3 months. At the end of the entire cycle of PE, almost complete recovery (more than 90% of the initial clinical score) was obtained in 8 of 18 patients while an improvement between 60 and 90% of the initial score was achieved in 9 of 18 patients. An early improvement was noted 24 h after the beginning of plasmapheresis in 11 of 18 patients. No recurrence of symptoms was reported after 36 months of follow-up for 17 patients. The administration of steroid therapy was never followed by an early exacerbation of myasthenic symptoms as reported when it is administered in the absence of concomitant PE. According to our results, we can conclude that high doses of oral prednisone therapy in simultaneous association with PE lead to successful control of severe forms of MG, significantly superior to the therapeutic strategies until now adopted and reported in literature.

AB - In this study we introduce a new combination treatment of plasma exchange (PE) and high daily doses of prednisone for severe forms of myasthenia gravis (MG). The clinical efficacy of the combined therapy has been tested in 18 patients suffering from severe forms of MG. The protocol included 5 sessions of PE, performed in a range of 15 days, 1 session every 3 days, with concurrent administration of oral prednisone (1 mg/kg of body weight), starting at the first session of PE and given daily for at least 3 months. At the end of the entire cycle of PE, almost complete recovery (more than 90% of the initial clinical score) was obtained in 8 of 18 patients while an improvement between 60 and 90% of the initial score was achieved in 9 of 18 patients. An early improvement was noted 24 h after the beginning of plasmapheresis in 11 of 18 patients. No recurrence of symptoms was reported after 36 months of follow-up for 17 patients. The administration of steroid therapy was never followed by an early exacerbation of myasthenic symptoms as reported when it is administered in the absence of concomitant PE. According to our results, we can conclude that high doses of oral prednisone therapy in simultaneous association with PE lead to successful control of severe forms of MG, significantly superior to the therapeutic strategies until now adopted and reported in literature.

KW - Myasthenia gravis

KW - Myasthenic crisis

KW - Plasma exchange

KW - Steroids and plasmapheresis

KW - Steroids in myasthenia

UR - http://www.scopus.com/inward/record.url?scp=0031934135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031934135&partnerID=8YFLogxK

U2 - 10.1046/j.1525-1594.1998.05061.x

DO - 10.1046/j.1525-1594.1998.05061.x

M3 - Article

C2 - 9491902

AN - SCOPUS:0031934135

VL - 22

SP - 129

EP - 134

JO - Artificial Organs

JF - Artificial Organs

SN - 0160-564X

IS - 2

ER -