Plasmatic and vascular factors of the hemostatic system in rats receiving an estrogen-progestogen combination

Maria Carla Roncaglioni, Giovanni di Minno, Jerta Pangrazzi, Ine Reyers, Luciana Mussoni, Giovanni de Gaetano, Maria Benedetta Donati

Research output: Contribution to journalArticle

Abstract

Treatment of rats for 10 estral cycles with an estrogen-progestogen combination giving 100% infertility triggered a vascular response characterized by increased prostacyclin activity in arterial walls and increased systolic blood pressure. In contrast, plasma fibrinolytic activity and physiological coagulation inhibitors as well as vascular fibrinolytic activity were not changed by this treatment. The same rats tended to have shorter occlusion times of an aortic prosthesis, and could represent a useful model to study the blood-vessel-wall interplay during oral contraceptive treatment.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalContraception
Volume22
Issue number3
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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