Plasmatic cytokine network in patients with laryngeal carcinoma after surgical treatment

Lorenzo Pignataro, Massimiliano M. Corsi, Giuseppe Sambataro, Luigi Porcaro, Paola Tredici, Guido Broich

Research output: Contribution to journalArticle

Abstract

Alterations in host immunity, inflammation, angiogenesis and metabolism are all prominent clinical features in patients with laryngeal squamous cell carcinoma (LSCC). Although the origin of the signals and mechanisms underlying these responses are not well understood, their local and systematic nature suggest that squamous cell carcinoma-produced cytokines with proinflammatory and immunoregulatory activity may contribute to the pathogenesis of LSCC. In order to gain a better insight into the roles and relationships of the cytokines, we investigated serum IL-6, IL-10 and IL-12 concentrations in LSCC patients under baseline conditions and after surgery. In comparison with controls, all the patients had higher plasma IL-10 concentrations before surgical treatment (T0), while plasma IL-6 and IL-12 concentrations were higher in 22 (84.6%) and 24 patients (92.3%). The differences in plasma IL-6, IL-10 and IL-12 concentrations at T0 and TI were statistically significant (p

Original languageEnglish
Pages (from-to)3621-3625
Number of pages5
JournalAnticancer Research
Volume21
Issue number5
Publication statusPublished - 2001

Keywords

  • Blood
  • Elisa
  • Interleukin-10
  • Interleukin-12
  • Interleukin-6
  • Laryngeal carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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