Plasmatic hippuric acid as a hallmark of frailty in an Italian cohort: the mediation effect of fruit-vegetable intake

Laura Brunelli, Annalisa Davin, Giovanna Sestito, Maria Chiara Mimmi, Giulia De Simone, Claudia Balducci, Orietta Pansarasa, Gianluigi Forloni, Cristina Cereda, Roberta Pastorelli, Antonio Guaita

Research output: Contribution to journalArticlepeer-review

Abstract

Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes and poor quality of life. This study was conducted in the framework of InveCe.Ab, an ongoing longitudinal population-based study. Plasma from 130 older individuals (older adults aged 76 to 78 years) was analysed and validated (on 303 subjects) using mass spectrometry-based metabolomics approaches. Equivalence tests showed that metabolites from the central cellular metabolic pathways were equivalent in Frail and Fit subjects. Hippuric acid was the only co-metabolite that distinguished Fit from Frail older adult. Logistic regression analysis indicated that high hippuric acid levels are significantly associated with a reduction of the risk of frailty after four years. Mediation analysis using a Frailty Index, hippuric acid and fruit-vegetable intake supported the role of fruit-vegetable consumption in the hippuric acid relationship with the Frailty Index. These data point to low plasma hippuric acid as a plausible hallmark of frailty status, associated with lower fruit-vegetable intakes.

Original languageEnglish
Pages (from-to)2081-9
Number of pages9
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume76
Issue number12
DOIs
Publication statusPublished - Aug 26 2021

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