The neuropeptide somatostatin (SRIF) is modulated in the hippocampal formation in experimental animal models of temporal lobe epilepsy (TLE), and may serve as an endogenous regulator to control neuronal hyperexcitability. Whereas plastic changes of SRIF interneurons were widely studied in kindling epileptogenesis, little is known about the status of SRIF receptors. During kindling epileptogenesis, a progressive decrease of sst2A immunoreactivity in the outer molecular layer was revealed, which was spatially associated with an increase in SRIF immunoreactivity. These results suggest that the decrease in sst2A receptor density in the outer molecular layer of dentate gyrus in kindling epileptogenesis represents a local receptor down-regulation due to chronic SRIF exposure. This phenomenon might contribute to granule cell hyperexcitability and consequently enhanced seizure activity.
|Translated title of the contribution||Plasticity of somatostatin and sst2A receptor in kindling epileptogenesis|
|Number of pages||9|
|Publication status||Published - Apr 2005|
- C protein-coupled receptors
- Dentate gyrus
ASJC Scopus subject areas
- Clinical Neurology