Plasticity of the motor cortex in Parkinson's disease patients on and off therapy

Sergio Bagnato; Rocco Agostino; Nicola Modugno; Angelo Quartarone; Alfredo Berardelli

doi:10.1002/mds.20778

Plasticity of the motor cortex in Parkinson's disease patients on and off therapy

Sergio Bagnato, Rocco Agostino, Nicola Modugno, Angelo Quartarone, Alfredo Berardelli

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Abstract

We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.

Original language	English
Pages (from-to)	639-645
Number of pages	7
Journal	Movement Disorders
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/mds.20778
Publication status	Published - May 2006

Keywords

Associative stimulation
Parkinson's disease
Plasticity
Sensorimotor integration
Transcranial magnetic stimulation (TMS)

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.20778

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AU - Quartarone, Angelo

AU - Berardelli, Alfredo

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