Plasticity of the motor cortex in Parkinson's disease patients on and off therapy

Sergio Bagnato, Rocco Agostino, Nicola Modugno, Angelo Quartarone, Alfredo Berardelli

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalMovement Disorders
Volume21
Issue number5
DOIs
Publication statusPublished - May 2006

Fingerprint

Motor Cortex
Parkinson Disease
Motor Evoked Potentials
Therapeutics
Neurons
Sensorimotor Cortex

Keywords

  • Associative stimulation
  • Parkinson's disease
  • Plasticity
  • Sensorimotor integration
  • Transcranial magnetic stimulation (TMS)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Plasticity of the motor cortex in Parkinson's disease patients on and off therapy. / Bagnato, Sergio; Agostino, Rocco; Modugno, Nicola; Quartarone, Angelo; Berardelli, Alfredo.

In: Movement Disorders, Vol. 21, No. 5, 05.2006, p. 639-645.

Research output: Contribution to journalArticle

Bagnato, Sergio ; Agostino, Rocco ; Modugno, Nicola ; Quartarone, Angelo ; Berardelli, Alfredo. / Plasticity of the motor cortex in Parkinson's disease patients on and off therapy. In: Movement Disorders. 2006 ; Vol. 21, No. 5. pp. 639-645.
@article{42920541589446f1af37bb4a77e88a4c,
title = "Plasticity of the motor cortex in Parkinson's disease patients on and off therapy",
abstract = "We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.",
keywords = "Associative stimulation, Parkinson's disease, Plasticity, Sensorimotor integration, Transcranial magnetic stimulation (TMS)",
author = "Sergio Bagnato and Rocco Agostino and Nicola Modugno and Angelo Quartarone and Alfredo Berardelli",
year = "2006",
month = "5",
doi = "10.1002/mds.20778",
language = "English",
volume = "21",
pages = "639--645",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Plasticity of the motor cortex in Parkinson's disease patients on and off therapy

AU - Bagnato, Sergio

AU - Agostino, Rocco

AU - Modugno, Nicola

AU - Quartarone, Angelo

AU - Berardelli, Alfredo

PY - 2006/5

Y1 - 2006/5

N2 - We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.

AB - We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.

KW - Associative stimulation

KW - Parkinson's disease

KW - Plasticity

KW - Sensorimotor integration

KW - Transcranial magnetic stimulation (TMS)

UR - http://www.scopus.com/inward/record.url?scp=33646920860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646920860&partnerID=8YFLogxK

U2 - 10.1002/mds.20778

DO - 10.1002/mds.20778

M3 - Article

C2 - 16353175

AN - SCOPUS:33646920860

VL - 21

SP - 639

EP - 645

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 5

ER -