Abstract
We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.
| Original language | English |
|---|---|
| Pages (from-to) | 639-645 |
| Number of pages | 7 |
| Journal | Movement Disorders |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2006 |
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Keywords
- Associative stimulation
- Parkinson's disease
- Plasticity
- Sensorimotor integration
- Transcranial magnetic stimulation (TMS)
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Plasticity of the motor cortex in Parkinson's disease patients on and off therapy. / Bagnato, Sergio; Agostino, Rocco; Modugno, Nicola; Quartarone, Angelo; Berardelli, Alfredo.
In: Movement Disorders, Vol. 21, No. 5, 05.2006, p. 639-645.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasticity of the motor cortex in Parkinson's disease patients on and off therapy
AU - Bagnato, Sergio
AU - Agostino, Rocco
AU - Modugno, Nicola
AU - Quartarone, Angelo
AU - Berardelli, Alfredo
PY - 2006/5
Y1 - 2006/5
N2 - We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.
AB - We used the paired associative stimulation (PAS) technique to investigate associative plasticity of the sensorimotor cortex in 16 Parkinson's disease (PD) patients off and on therapy and in 10 age-matched controls. After PAS, motor evoked potential (MEP) amplitudes increased more and the cortical silent period showed a reduced prolongation in patients off therapy than in controls. These changes lasted for at least 30 minutes. In addition, MEP amplitudes increased in a less focal manner in patients off therapy than in controls. After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex.
KW - Associative stimulation
KW - Parkinson's disease
KW - Plasticity
KW - Sensorimotor integration
KW - Transcranial magnetic stimulation (TMS)
UR - http://www.scopus.com/inward/record.url?scp=33646920860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646920860&partnerID=8YFLogxK
U2 - 10.1002/mds.20778
DO - 10.1002/mds.20778
M3 - Article
C2 - 16353175
AN - SCOPUS:33646920860
VL - 21
SP - 639
EP - 645
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 5
ER -