Platelet [3H]paroxetine binding in patients with OCD-related disorders

Donatella Marazziti, Liliana Dell'Osso, Silvio Presta, Chiara Pfanner, Alessandra Rossi, Irene Masala, Stefano Baroni, Gino Giannaccini, Antonio Lucacchini, Giovanni Battista Cassano

Research output: Contribution to journalArticlepeer-review

Abstract

The recently introduced notion of clinical conditions being related one to another, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypotheses yet exist. We therefore compared the binding of [3H]paroxetine ([3H]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [3H]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [3H]Par binding sites in both patient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalPsychiatry Research
Volume89
Issue number3
DOIs
Publication statusPublished - Dec 27 1999

Keywords

  • [H]Paroxetine binding
  • Obsessive-compulsive disorder (OCD)
  • OCD spectrum disorders
  • Platelets
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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