Platelet [3H]paroxetine binding in patients with OCD-related disorders

Donatella Marazziti, Liliana Dell'Osso, Silvio Presta, Chiara Pfanner, Alessandra Rossi, Irene Masala, Stefano Baroni, Gino Giannaccini, Antonio Lucacchini, Giovanni Battista Cassano

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The recently introduced notion of clinical conditions being related one to another, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypotheses yet exist. We therefore compared the binding of [3H]paroxetine ([3H]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [3H]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [3H]Par binding sites in both patient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalPsychiatry Research
Volume89
Issue number3
DOIs
Publication statusPublished - Dec 27 1999

Fingerprint

Paroxetine
Obsessive-Compulsive Disorder
Disruptive, Impulse Control, and Conduct Disorders
Serotonin
Blood Platelets
Healthy Volunteers
Trichotillomania
Body Dysmorphic Disorders
Tourette Syndrome
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Binding Sites
Ligands
Membranes
Pharmaceutical Preparations

Keywords

  • [H]Paroxetine binding
  • Obsessive-compulsive disorder (OCD)
  • OCD spectrum disorders
  • Platelets
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Marazziti, D., Dell'Osso, L., Presta, S., Pfanner, C., Rossi, A., Masala, I., ... Cassano, G. B. (1999). Platelet [3H]paroxetine binding in patients with OCD-related disorders. Psychiatry Research, 89(3), 223-228. https://doi.org/10.1016/S0165-1781(99)00102-X

Platelet [3H]paroxetine binding in patients with OCD-related disorders. / Marazziti, Donatella; Dell'Osso, Liliana; Presta, Silvio; Pfanner, Chiara; Rossi, Alessandra; Masala, Irene; Baroni, Stefano; Giannaccini, Gino; Lucacchini, Antonio; Cassano, Giovanni Battista.

In: Psychiatry Research, Vol. 89, No. 3, 27.12.1999, p. 223-228.

Research output: Contribution to journalArticle

Marazziti, D, Dell'Osso, L, Presta, S, Pfanner, C, Rossi, A, Masala, I, Baroni, S, Giannaccini, G, Lucacchini, A & Cassano, GB 1999, 'Platelet [3H]paroxetine binding in patients with OCD-related disorders', Psychiatry Research, vol. 89, no. 3, pp. 223-228. https://doi.org/10.1016/S0165-1781(99)00102-X
Marazziti, Donatella ; Dell'Osso, Liliana ; Presta, Silvio ; Pfanner, Chiara ; Rossi, Alessandra ; Masala, Irene ; Baroni, Stefano ; Giannaccini, Gino ; Lucacchini, Antonio ; Cassano, Giovanni Battista. / Platelet [3H]paroxetine binding in patients with OCD-related disorders. In: Psychiatry Research. 1999 ; Vol. 89, No. 3. pp. 223-228.
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