Abstract
The recently introduced notion of clinical conditions being related one to another, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypotheses yet exist. We therefore compared the binding of [3H]paroxetine ([3H]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [3H]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [3H]Par binding sites in both patient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 223-228 |
| Number of pages | 6 |
| Journal | Psychiatry Research |
| Volume | 89 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 27 1999 |
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Keywords
- [H]Paroxetine binding
- Obsessive-compulsive disorder (OCD)
- OCD spectrum disorders
- Platelets
- Serotonin
- Serotonin transporter
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Platelet [3H]paroxetine binding in patients with OCD-related disorders. / Marazziti, Donatella; Dell'Osso, Liliana; Presta, Silvio; Pfanner, Chiara; Rossi, Alessandra; Masala, Irene; Baroni, Stefano; Giannaccini, Gino; Lucacchini, Antonio; Cassano, Giovanni Battista.
In: Psychiatry Research, Vol. 89, No. 3, 27.12.1999, p. 223-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Platelet [3H]paroxetine binding in patients with OCD-related disorders
AU - Marazziti, Donatella
AU - Dell'Osso, Liliana
AU - Presta, Silvio
AU - Pfanner, Chiara
AU - Rossi, Alessandra
AU - Masala, Irene
AU - Baroni, Stefano
AU - Giannaccini, Gino
AU - Lucacchini, Antonio
AU - Cassano, Giovanni Battista
PY - 1999/12/27
Y1 - 1999/12/27
N2 - The recently introduced notion of clinical conditions being related one to another, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypotheses yet exist. We therefore compared the binding of [3H]paroxetine ([3H]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [3H]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [3H]Par binding sites in both patient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - The recently introduced notion of clinical conditions being related one to another, the spectrum concept, permits the testing of the involvement of serotonergic systems in a broad range of disorders tentatively linked to obsessive-compulsive disorder (OCD) for which no pathophysiological hypotheses yet exist. We therefore compared the binding of [3H]paroxetine ([3H]Par), a ligand that specifically labels the serotonin (5-HT) transporter, in platelets of drug-free outpatients suffering from various OCD-related disorders with binding in platelets of OCD patients and healthy subjects. Diagnoses were made according to DSM-IV criteria. The most frequent diagnosis was that of body dysmorphic disorder, followed by impulse control disorder, kleptomania, Tourette's syndrome and trichotillomania. Platelet membranes and [3H]Par binding were studied according to standardized protocols. The results, showing a similarly decreased density of [3H]Par binding sites in both patient groups as compared with healthy subjects, suggest the presence of a shared abnormality at the level of the presynaptic 5-HT transporter, probably linked to a common dimension yet to be identified. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - [H]Paroxetine binding
KW - Obsessive-compulsive disorder (OCD)
KW - OCD spectrum disorders
KW - Platelets
KW - Serotonin
KW - Serotonin transporter
UR - http://www.scopus.com/inward/record.url?scp=0033233296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033233296&partnerID=8YFLogxK
U2 - 10.1016/S0165-1781(99)00102-X
DO - 10.1016/S0165-1781(99)00102-X
M3 - Article
C2 - 10708268
AN - SCOPUS:0033233296
VL - 89
SP - 223
EP - 228
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -