Abstract
In previous work we showed that platelet-activating factor (PAF) was produced upon stimulation of the chick retina with acetylcholine (ACh) and dopamine (DA), via a dithiothreitol-insensitive cholinephosphotransferase (DTT-CPT). Other neurotransmitters were ineffective. Since ACh and DA stimulated PAF production at different stages of development, we advanced the hypothesis that selected cholinergic and dopaminergic receptors were involved. In this paper we demonstrate that only muscarinic or D2 (and not D1 and nicotinic) receptor stimulation induced PAF production in the chick retina either before or after hatching. Moreover, our data show that PAF production was completely prevented by blockage of these receptors by specific antagonists. These data further substantiate the hypothesis that PAF synthesis could be physiologically associated with synapse stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 283-288 |
| Number of pages | 6 |
| Journal | Journal of Lipid Mediators |
| Volume | 1 |
| Issue number | 5 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
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Platelet-activating factor production occurs through stimulation of cholinergic and dopaminergic receptors in the chick retina. / Bussolino, F.; Torelli, S.; Stefanini, E.; Gremo, F.
In: Journal of Lipid Mediators, Vol. 1, No. 5, 1989, p. 283-288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Platelet-activating factor production occurs through stimulation of cholinergic and dopaminergic receptors in the chick retina
AU - Bussolino, F.
AU - Torelli, S.
AU - Stefanini, E.
AU - Gremo, F.
PY - 1989
Y1 - 1989
N2 - In previous work we showed that platelet-activating factor (PAF) was produced upon stimulation of the chick retina with acetylcholine (ACh) and dopamine (DA), via a dithiothreitol-insensitive cholinephosphotransferase (DTT-CPT). Other neurotransmitters were ineffective. Since ACh and DA stimulated PAF production at different stages of development, we advanced the hypothesis that selected cholinergic and dopaminergic receptors were involved. In this paper we demonstrate that only muscarinic or D2 (and not D1 and nicotinic) receptor stimulation induced PAF production in the chick retina either before or after hatching. Moreover, our data show that PAF production was completely prevented by blockage of these receptors by specific antagonists. These data further substantiate the hypothesis that PAF synthesis could be physiologically associated with synapse stimulation.
AB - In previous work we showed that platelet-activating factor (PAF) was produced upon stimulation of the chick retina with acetylcholine (ACh) and dopamine (DA), via a dithiothreitol-insensitive cholinephosphotransferase (DTT-CPT). Other neurotransmitters were ineffective. Since ACh and DA stimulated PAF production at different stages of development, we advanced the hypothesis that selected cholinergic and dopaminergic receptors were involved. In this paper we demonstrate that only muscarinic or D2 (and not D1 and nicotinic) receptor stimulation induced PAF production in the chick retina either before or after hatching. Moreover, our data show that PAF production was completely prevented by blockage of these receptors by specific antagonists. These data further substantiate the hypothesis that PAF synthesis could be physiologically associated with synapse stimulation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024419273&partnerID=8YFLogxK
M3 - Article
C2 - 2519898
AN - SCOPUS:0024419273
VL - 1
SP - 283
EP - 288
JO - Journal of Lipid Mediators
JF - Journal of Lipid Mediators
SN - 0921-8319
IS - 5
ER -